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B-Col10a1-iCre mice

The Col10a1 gene encodes a short-chain minor collagen of cartilage which is a direct transcriptional target of RUNX2 during chondrogenesis.

 

B-Col10a1-iCre mice

(C57BL/6-Col10a1tm1(iCre)/Bcgen)

Gene Targeting Strategy 

B-Col10al-iCre mice.png

Description

The Col10a1 gene encodes a short-chain minor collagen of cartilage which is a direct transcriptional target of RUNX2 during chondrogenesis. In this strain, Cre recombinase expression is under the control of Col10a1 promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in Col10a1 expressing cells.

Phenotype

Mice hemizygous for Col10a1iCre gene are viable and fertile without any physical abnormalities.

(B-EM-001) B-Col10a1-iCre mice

 

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