Gene Targeting Strategy
The Ncr1 gene, also called Nkp46, encodes the natural cytotoxicity triggering receptor 1. This protein is expressed specifically in natural killer (NK) cells and possibly in related innate lymphocytes. In this strain, Cre recombinase expression is under the control of Ncr1 promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in Ncr1 expressing cells.
Mice hemizygous for Ncr1iCre gene are viable and fertile without any physical abnormalities.
(B-EM-006) B-Ncr1(Nkp46)-iCre mice