Gene Targeting Strategy
The Dmp1 gene encodes the dentin matrix acidic phosphoprotein 1, an extracellular matrix protein and a member of the small integrin-binding ligand N-linked glycoprotein family. This protein is critical for proper mineralization of bone and dentin. In this strain, Cre recombinase expression is under the control of Dmp1 promoter in a bone and tooth tissue pattern. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in Dmp1 expressing cells.
Mice hemizygous for Dmp1iCre gene are viable and fertile without any physical abnormalities.
(B-EM-003) B-Dmp1-iCre mice 【Return list】