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B-Dmp1-iCre mice

The Dmp1 gene encodes the dentin matrix acidic phosphoprotein 1, an extracellular matrix protein and a member of the small integrin-binding ligand N-linked glycoprotein family.

B-Dmp1-iCre mice

(C57BL/6-Dmp1tm1(iCre)/Bcgen)

Gene Targeting Strategy

B-Dmp1-iCre mice.png

Description

The Dmp1 gene encodes the dentin matrix acidic phosphoprotein 1, an extracellular matrix protein and a member of the small integrin-binding ligand N-linked glycoprotein family. This protein is critical for proper mineralization of bone and dentin. In this strain, Cre recombinase expression is under the control of Dmp1 promoter in a bone and tooth tissue pattern. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in Dmp1 expressing cells.

Phenotype

Mice hemizygous for Dmp1iCre gene are viable and fertile without any physical abnormalities.

(B-EM-003) B-Dmp1-iCre mice

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