Biocytogen 

Preclinical Services

>CDX tumor model

Tumor cells & CDX animals for in vivo imaging

The traditional tumor cells model(Cell line-Derived Xenograft, CDX) is a well established model in the research and development process of tumor drugs. The model is easy to establish and has good reproducibility, so it is still largelyin demand for the research and development of tumor drugs. The CDX model is established by inoculating long-term, in vitro passaged tumor cells into immune deficient mice, featuring high homology due to cell homogeneity. 

Available services: We provide various cell line tumor models according to the customer’s requirements for research and development, establishment of subcutaneous, orthotopic, or metastatic tumor models. We also provide in vivo pharmacological and pharmacodynamic services for the corresponding models. 

Animal type: Wildtype; immuno-deficient mice.


Established CDX models


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CDX models with luciferase labeled cell lines and in vivo imaging

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Established CDX models in vivo

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Fig 1. In vivo imaging of B-NDG mice 0, 13, and 18 days after tail vein injection with 5x10Raji-Luc cells.


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Fig 2. In vivo imaging of  C57BL/6  mice 0, 14, and 23 days after tail vein injection with 5x106  MC38-Luc cells.


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Fig 3. (A) In vivo imaging of NOD-scid mice at 6, 16, and 28 days after inoculation with HT-29-GFP Luciferase cells. The mouse on left was No. 4: injected with 5x106 cells; The mouse on right was No. 3: injected in 5x105 cells. (B) Signal intensity of tumor cells in vivo.


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Fig 4. (A) In vivo imaging of NOD-scid mice at 7, 14, and 21 days after inoculation with 4T1-Luciferase cells. The mouse on left was No. 6: injected in 5x106cells; The mice on right was No. 5: injected with 5x105 cells. (B) Signal intensity of tumor cells in vivo.

                                    



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