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B-Slc6a3(Dat1)-Cre rats

The Slc6a3 gene encodes the dopamine transporter (DAT), which mediates the active reuptake of dopamine from the synapse and is a principal regulator of dopaminergic neurotransmission.

B-Slc6a3(Dat1)-Cre rats

(SD-Slc6a3tm1(Cre)/Bcgen)

Gene Targeting Strategy

B-Slc6a3(Dat1)-Cre rats.png

Description

The Slc6a3 gene encodes the dopamine transporter (DAT), which mediates the active reuptake of dopamine from the synapse and is a principal regulator of dopaminergic neurotransmission. In this strain, Cre recombinase expression is under the control of Slc6a3 promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in Slc6a3 expressing cells.

Phenotype

Rats hemizygous for Slc6a3Cre gene are viable and fertile without any physical abnormalities.

(B-CR-008) B-Slc6a3(Dat1)-Cre rats

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