Gene Targeting Strategy
The Slc6a3 gene encodes the dopamine transporter (DAT), which mediates the active reuptake of dopamine from the synapse and is a principal regulator of dopaminergic neurotransmission. In this strain, Cre recombinase expression is under the control of Slc6a3 promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in Slc6a3 expressing cells.
Rats hemizygous for Slc6a3Cre gene are viable and fertile without any physical abnormalities.
(B-CR-008) B-Slc6a3(Dat1)-Cre rats 【Return list】