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Animal Models and Cell Lines

>Cre rat models

B-Kit-CreERT2 rats

The Kit gene encodes the tyrosine kinase receptor KIT, KITand its ligand, KITLG, function in hematopoiesis, melanogenesis, and gametogenesis. 

B-Kit-CreERT2 rats

(SD-Kittm1(Cre/ETR2)/Bcgen)

 

Gene Targeting Strategy

B-Kit-CreERT2 rats.png

 

Description

The Kit gene encodes the tyrosine kinase receptor KIT, KITand its ligand, KITLG, function in hematopoiesis, melanogenesis, and gametogenesis. In this strain, Cre recombinase expression is under the control of Kit promoter. When crossed with a strain containing a loxP site-flanked sequence of interest and treated with tamoxifen, Cre-mediated recombination results in deletion of the flanked sequence in Kit expressing cells.

Phenotype

Rats hemizygous for KitCreERT2 gene are viable and fertile without any physical abnormalities.

 


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