Gene Targeting Strategy
The Drd2 gene encodes dopamine receptor D2. In this strain, Cre recombinase expression is under the control of Drd2 promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in Drd2 expressing cells.
Rats hemizygous for Drd2Cre gene are viable and fertile without any physical abnormalities.
(B-CR-003) B-Drd2-Cre rats 【Return list】