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Animal Models and Cell Lines

>Genetically modified rats

Brief introduction: Interleukin receptor gamma chain (IL2RG) is a receptor element of multiple interleukin signal pathways, comprised of interleukin-2, -4, -7 and -21. Mutation of this gene can cause X-linked severe combined immunodeficiency diseases.

IL2rg KO rats.png

Targeting strategy:

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Brief introduction: Brief introduction: Interleukin receptor gamma chain (IL2RG) is a receptor element of multiple interleukin signal pathways, comprised of interleukin-2, -4, -7 and -21. Mutation of this gene can cause X-linked severe combined immunodeficiency diseases.

Phenotypic characteristics: Applications for immunity, inflammation, tumor, heterograft, and transplantation studies.

 

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