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Animal Models and Cell Lines

>Genetically modified rats

LDLR is widely distributed in the liver, the smooth muscle cells of artery wall, adrenocortical cells, vascular endothelial cells, lymphocytes, monocytes and macrophages. LDL receptors of different tissues and cells are largely different in activity.

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Targeting strategy:


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Brief introduction: Low density lipoprotein receptor (LDLR) is a multifunctional surface body structural protein formed by 836 amino acid residues, with a molecular weight of about 115kD. LDLR consists of five different regions, and each region has a unique function.
LDLR is widely distributed in the liver, the smooth muscle cells of artery wall, adrenocortical cells, vascular endothelial cells, lymphocytes, monocytes and macrophages. LDL receptors of different tissues and cells are largely different in activity. LDL or other lipoproteins containing ApoB100 and E, such as VLDL (very low density lipoprotein), can all bind to the LDL receptor to enter into cells through LDL receptor pathway, resulting in lipid production. Plasma cholesterol is mainly contained in LDL, and 65-70% of LDL can be eliminated depending on LDL receptor on liver cells. The liver LDL receptor can also affect the synthesis rate of LDL and VLDL metabolism.

Phenotypic characteristics: Rats have large organs and blood capacity, are easy to operate on, the gene, physiology and behavior of rats are more approximate to human beings than mice, and are ideal pre-clinical test animals. LDLR (low density lipoprotein receptor) gene knockout (-/-) rats are ideal animal models for atherosclerosis. This gene knockout model can also be applied to disease studies such as hypertension, hyperlipidemia, obesity and type-II diabetes.

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