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Animal Models and Cell Lines

>Double Humanized Immune-Checkpoint Mice

Basic characteristics

 

Strain Name

C57BL/6-Pdcd1tm1(hPDCD1)Btlatm1(hBTLA)/Bcgen

Common Name

B-hPD-1/hBTLA mice

Background

C57BL/6

Catalog number

B-DM-002

Catalog number (Males)

BDM002M

Catalog number (Females)

BDM002F

Related Genes

PD-1(Programmed death-1) ;

BTLA(B and T lymphocyte associated)

 

Targeting strategy


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Protein Expression Analysis

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Fig 1. Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/hBTLA mice were analyzed by flow cytometry. 

Mouse BTLA+ B cells were detected in the WT C57BL/6 mice, while human BTLA+ B cells were detected in the homozygous B-hPD-1/hBTLA mice.

 

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Fig 2. Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/hBTLA mice were analyzed by flow cytometry. 

Mouse PD-1+ T cells were detected in the WT C57BL/6 mice, while human PD-1+ T cells were detected in the homozygous B-hPD-1/hBTLA mice.

 

 

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