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Animal Models and Cell Lines

>Double Humanized Immune-Checkpoint Mice

B-hPD-1/hCD27mice


Basic characteristics

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Targeting strategy

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Protein expression analysis

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Fig 1. Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/hCD27 mice were analyzed by flow cytometry. Mouse CD27+ T cells were detectable in both WT C57BL/6 and the homozygous B-hPD-1/hCD27 mice, while human CD27+ T cells were detectable in the homozygous B-hPD-1/hCD27 mice. This might result from the cross-recognition of hCD27 by anti-mCD27 antibodies.



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Fig 2. Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/hCD27 mice were analyzed by flow cytometry. Mouse PD-1+ T cells were detectable in the WT C57BL/6 mice, while human PD-1+ T cells were detectable in the homozygous B-hPD-1/hCD27 mice.




 

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