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Animal Models and Cell Lines

>Double Humanized Immune-Checkpoint Mice

B-hCTLA4/hOX40 mice


Basic characteristics

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Targeted allele

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Protein expression analysis

 

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Fig 1. Splenocytes B-hCTLA4/hOX40 mice were analyzed by flow cytometry.

Mouse CTLA4+ cells were detectable in WT C57BL/6, while human CTLA4+ cells were detectable in the homozygous B-hCTLA4/hOX40 mice.



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Fig 2. Splenocytes from homozygous B-hCTLA4/hOX40 mice were analyzed by flow cytometry.

Mouse OX40+ cells were detectable in wild type (WT) C57BL/6, while human OX40+ cells were detectable in the homozygous B-hCTLA4/hOX40 mice.


Combination Therapy of CTLA4 mAb (Yervoy) and OX40 mAb


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Fig 3. Murine colon cancer MC38 cells were subcutaneously implanted into homozygous B-hCTLA4/hOX40 mice. Mice were grouped when the tumor size was approximately 150±50 mm3 (n=8). Anti-hCTLA4 antibody Yervoy and the anti-hOX40 antibody shows obviously inhibitory effects respectively. Combination of Anti-hCTLA4 antibody Yervoy and the anti-hOX40 antibody shows better inhibitory effects than single treatment, suggesting that  B-hCTLA4/hOX40 mouse is a powerful tool for in vivo evaluating combination therapy efficacy of hCTLA4 antibody and hOX40 antibody.


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