Biocytogen 

Animal Models and Cell Lines

>Double Humanized Immune-Checkpoint Mice

B-hCTLA4/h4-1BB mice


Basic characteristics

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Targeting strategy

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Protein expression analysis
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Fig 1. Splenocytes from homozygous B-hCTLA4/h4-1BB mice were analyzed by flow cytometry.

m4-1BB+ cells were detectable in wild type (WT) C57BL/6, h4-1BB+ cells were detectable in the homozygous B-hCTLA4/h4-1BB mice.


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Fig 2. Splenocytes from homozygous B-hCTLA4/h4-1BB mice were analyzed by flow cytometry.

mCTLA4+ cells were detectable in wild type (WT) C57BL/6, while hCTLA4+ cells were detectable in the homozygous B-hCTLA4/h4-1BB mice.



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