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Animal Models and Cell Lines

>Double Humanized Immune-Checkpoint Mice

B-hPD-L1/hLAG3 mice


Basic characteristics

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Targeting strategy

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Protein expression analysis

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Fig 1. Splenocytes B-hPD-L1/hLAG3 mice were analyzed by flow cytometry.

mLAG3+ cells were detectable in C57BL/6 mice, while hLAG3+ cells were detectable in the homozygous B-hPD-L1/hLAG3 mice. Detection of mLAG3+ cells in B-hPD-L1/hLAG3 mice might caused by mouse antibody cross reactivity.  


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Fig 2. Splenocytes B-hPD-L1/hLAG3 mice were analyzed by flow cytometry.

mPD-L1+ cells were detectable in C57BL/6 mice, while hPD-L1+ cells were detectable in the homozygous B-hPD-L1/hLAG3 mice.





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