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>ESC Based Gene Gene KO/KI Targeting



A humanized mouse model means that the mouse model possesses a functional human gene, cell or tissue. Such models are  generally used as the living body substitutes for in vivo studies of human diseases.

A humanized mouse model means that the mouse model possesses a functional human gene, cell or tissue. Such models are  generally used as the living body substitutes for in vivo studies of human diseases, and have wide applications in  AIDS, cancer, infectious disease, human degenerative disease and blood disease research. Since there are obvious differences between human and mouse physiology, sometimes the  experimental  results obtained in regular animals are not applicable to human. Here we refer only to gene-humanized mouse models.  Generating a gene-humanized mouse model by using transgenesis or homologous  recombination is an effective tool for studying human diseases.

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