>Single Humanized Immune-Checkpoint Mice
- B-hCD274(PD-L1) mice
- PD-L1 is highly expressed in a variety of solid tumors. PD1 and PD-L1 interactions reduce T cell activation and promote tumor immune escape.
- B-hSIRPA mice
- The interruption of SIRPα -CD47 interaction substantially inhibits a variety of tumors. SIRPα/CD47 targeting antibodies are considered as promising targets for cancer immunotherapy following PD-1/PD-L1 antibodies.
- B-hTIGIT mice
- TIGIT is highly expressed in cancer tissues and competitively binds to TIGIT receptors with DNAM-1 proteins on the surface of NK cells to reduce the NK cell killing efficiency of cancer cells.
- B-hHAVCR2 (TIM3) mice
- TIM3 maturation and cell surface expression is facilitated by forming a heterodimeric interaction with CD66a. Co-blockade of CD66a and TIM3 enhanced anti-tumor immune responses, and eliminated tumors in mouse colorectal cancer models.