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B-hPD-1 mice
PD-1 interacts with its ligands and plays an important role in the negative regulation of the immune response.
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B-hCD274(PD-L1) mice
PD-L1 is highly expressed in a variety of solid tumors. PD1 and PD-L1 interactions reduce T cell activation and promote tumor immune escape.
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B-CTLA4 mice
The inhibition of CTLA4 by its inhibitory antibodies enhances T cell activity. The CTLA4 antibody is the first FDA-approved antibody to treat advanced melanoma.
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B-hTNFRSF4(OX40) mice
The coactivation of OX40/OX40L enhances T cell function, including cytokine production, proliferation and T cell survival. An OX40 agonist can reduce Regulatory T cells (Tregs) and improve anti-tumor activity.
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B-hCD137(4-1BB) mice
This co-stimulatory signal can also multiply antigen presenting cells and result in cell factor secretion. Experiments show that CD137 co-stimulation regulates T cell and antigen presenting cell function for antitumor immunity, providing new targets for tumor immunological therapies.
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B-hCD27 mice
Treating mice with a CD27 agonist antibody effectively enhanced the antitumor immune response for lymphoma and B16 melanoma, providing putative targets for tumor immunotherapy.
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