Knockin mouse models introduce mutant or
into a specific locus on the mouse genome to mimic genetic diseases or monitorgene
expression with reporter genes (e.g. EGFP, mRFP, mCherry, YFP, LacZ, Flag, etc.). The gene reporter mouse
models are also used to construct phylogenetictrees for cell developmentstudies.
Replacement of the endogenous gene with a reporter can simultaneously achieve
gene knockoutand knockin in
the same mouse model.