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Humanized mouse model

1.Definition

A mouse model with a functional human gene, cell, tissue, or organ, which is used as living body substitution model for human disease study. This service refers to the model with the functional human gene.

2.Advantages and disadvantages

Advantages: the human gene is expressed in the mouse body using the promoter and regulation region of the mouse gene.

Disadvantages: to ensure that the human gene is physiologically expressed and regulated normally in the mouse genome, the sequence and structure information of the genes and proteins should be analyzed in depth before designing, and comprehensive risk assessments should be built.

3. Principle

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A humanized mouse model with a functional human gene is constructed by replacing part or all of the mouse gene with the human gene. The expression of the human protein in the mouse body is the same as the mouse protein's expression, but the protein or functional region(s) of the mouse protein is not expressed in any cells or tissues.

4. Application

Human gene expression and functional studies

Human disease studies, such as AIDS, cancer, infectious diseases, human degenerative diseases, and blood diseases, etc.

Preclinical drug study

Compound safety evaluation


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