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IL-17/IFN-γ double producing CD8+ T(Tc17/IFN-γ)...

2016-06-07 16:17:12.0

Abstract
It has been reported that IFN-γ-producing CD8(+) T (Tc1) cells express cytotoxic molecules such asperforin and granzyme B to exhibit higher cytotoxicity against tumor cellscompared with Tc2 cells. However, the critical role of IL-17-producing CD8(+) T(Tc17)-cell subsets in tumor immunity remains unclear. Tc17 cells differentiated from naive CD8(+) T cells did not possess cytotoxic molecules and exhibited no strong cytotoxicity. However, when Tc17 effector cells were further cultured with IL-12, they converted into IFN-γ-producing Tc17 cells,which mainly consisted of IL-17/IFN-γ double-producing cells (Tc17/IFN-γ).IL-12-converted Tc17 cells also acquired cytotoxic function in addition to IFN-γ producibility. Moreover, they showed strong anti-tumor activity both invitro and in vivo as well as Tc1 cells. Among four distinct subsets in IL-12-converted Tc17 cell populations, the isolated Tc17/IFN-γ cells exhibitedcytotoxicity as well as IFN-γ-producing Tc1-like cells. Thus, we first indicate direct evidence that Tc17/IFN-γ cells, which were plastically converted from non-cytotoxic Tc17 cells by IL-12, exhibited strong anti-tumor activity as wellas Tc17 cell-derived Tc1-like cells.

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