Series of immune checkpoint humanized mice
Tumor immunotherapy is one of the most promising research fields in the field of tumor therapy. Major pharmaceutical companies have cooperated with other companies to develop tumor immunity-related treatment methods. Preliminary clinical trial results showed that the treatment efficacy is very high. Thus, Science magazine ranked tumor immunotherapy to be first place in the top ten scientific breakthroughs in 2013.
Immune checkpoints are important functional components of the body's immune system that regulate the this system by increasing (activating the immune-checkpoint) or decreasing (suppressing the immune-checkpoint) immune signals. Many cancer cells express proteins that can act on certain immune checkpoints by avoiding the killing of T cells and then escaping from the immune system. In recent years, immune checkpoint drugs have become an important novel cancer treatment. Biocytogen prepared a series of immune checkpoint humanized mice, and validated the mouse model efficacy with human antibodies, providing an effective model and powerful tool for antibody verification of immune checkpoint.
Basic characteristics of Biocytogen’s series of humanized mice with immune-checkpoint:
Stable C57BL/6 genetic background leads to more uniform and reliable experimental results!
Biocytogen’s series of humanized, immune checkpoint mice are all developed using the C57BL/6 genetic background. C57BL/6 background mice are inbred mice and are the currently accepted strain used in oncology, physiology, immunology and genetics studies. Using these mice will yield experimental results of high precision, good comparability, and stress response uniformity, so that your efficacy test results are more uniform and reliable.
Years of humanized mice design experience makes your validation of humanized drugs more reliable and dependable!
Biocytogen uses a wealth of experience in animal model development, particularly humanized mouse design experience, to fully consider all factors that may interfere with the expression of humanized proteins and to perform a detailed assessment and accurate design for each project. Ensuring sufficient humanization and humanized protein expression and signal transmission without external influences, a series of humanized mice are developed, so that your humanized immune checkpoint antibodies and inhibitors will be verified more reliably and dependably.
Oncology Meets Immunology: The Cancer-Immunity Cycle
Daniel S. Chen, Ira Mellman. 2013