The traditional tumor cells model（Cell line-Derived Xenograft, CDX) is a well established model in the research and development process of tumor drugs. The model is easy to establish and has good reproducibility, so it is still largelyin demand for the research and development of tumor drugs. The CDX model is established by inoculating long-term, in vitro passaged tumor cells into immune deficient mice, featuring high homology due to cell homogeneity.
Available services: We provide various cell line tumor models according to the customer’s requirements for research and development, establishment of subcutaneous, orthotopic, or metastatic tumor models. We also provide in vivo pharmacological and pharmacodynamic services for the corresponding models.
Animal type: Wildtype; immuno-deficient mice.
Established CDX models
Solid tumor cell lines
|Lung carcinoma, non-small cell||NCI-H1975 |
|Lung adenocarcinoma ||HCC827 |
|Lung Carcinoma ||NCI-H520|
|Lung Carcinoma||A549 |
|Lung carcinoma bronchoalveolar ||NCI-H1781 |
|Colorectal Ileocecal Adenocarcinoma ||HCT-8 |
|Colorectal adenocarcinoma ||HT-29|
|Breast Carcinoma ||DU4475|
|Epidermoid carcinoma||A-431 |
|Breast Adenocarcinoma ||MCF7|
|Acute myeloid leukemia (AML) ||MV4-11 |
|Acute myeloid leukemia (AML) ||KG-1 |
|Chronic myelogenous leukemia (CML)||K562|
|Acute myeloblastic leukemia ||Kasumi-1 |
|CD33+ acute myeloblastic leukemia (AML) ||NAMALWA |
|Burkitt's lymphoma (B cell) ||Daudi|
|Burkitt's lymphoma ||Raji |
|Lung Carcinoma ||LLC1 |
|Breast Carcinoma ||4T1 |
|Melanoma ||B16-F10 |
|Hepatoma ||Hepa1-6 |
Established CDX models in vivo
|Cell Name||Cancer Type||Organism|
|BCG-PS-087-luc ||B-luciferase-GFP Raji Cell Line ||Lymphoma, Burkitt's||Human|
|BCG-PS-056-luc||B-luciferase-GFP HT-29 Cell Line||Colorectal adenocarcinoma||Human|
|BCG-PS-022-luc||B-luciferase-GFP H-1975 Cell Line||Lung carcinoma, non-small cell||Human|
|BCG-PS-015-luc ||B-luciferase K562 Cell Lin e||Leukemia (CML)||Human |
|BCG-PS-018-luc ||B-luciferase 4T1 Cell Line ||Breast Carcinoma ||Murine|
|BCG-PS-019-luc ||B-luciferase B16-F10 Cell Line||Melanoma||Murine|
|BCG-PS-033-luc||B-luciferase MIA PaCa-2 Cell Line||Pancreatic carcinoma ||Human |
|BCG-PS-103-luc||B-luciferase MC38 Cell Line||Colorectal adenocardinoma||Murine|
|BCG-PS-016-luc ||B-luciferase U-87MG cell line ||Glioblastoma||Human|
Fig 1. In vivo imaging of B-NDG mice 0, 13, and 18 days after tail vein injection with 5x106 Raji-Luc cells.
Fig 2. In vivo imaging of C57BL/6 mice 0, 14, and 23 days after tail vein injection with 5x106 MC38-Luc cells.
A D7 D14 D21