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Tumor cells & CDX animals for in vivo imaging

2017-05-25 16:10:38.0

The traditional tumor cells model(Cell line-Derived Xenograft, CDX) is a well established model in the research and development process of tumor drugs. The model is easy to establish and has good reproducibility, so it is still largelyin demand for the research and development of tumor drugs. The CDX model is established by inoculating long-term, in vitro passaged tumor cells into immune deficient mice, featuring high homology due to cell homogeneity.


Available services: We provide various cell line tumor models according to the customer’s requirements for research and development, establishment of subcutaneous, orthotopic, or metastatic tumor models. We also provide in vivo pharmacological and pharmacodynamic services for the corresponding models. 

Animal type: Wildtype; immuno-deficient mice.


Established CDX models










        Solid tumor cell lines

Tumor type

Cell lines

Lung carcinoma, non-small cellNCI-H1975 
Lung adenocarcinoma 
HCC827 
Lung Carcinoma 
NCI-H520
Lung CarcinomaA549 
Lung carcinoma bronchoalveolar 
NCI-H1781 
Colorectal Ileocecal Adenocarcinoma 
HCT-8 
Colon CarcinomaHCT-116
Colorectal adenocarcinoma 
HT-29
GlioblastomaLN-229 
Breast Carcinoma 
DU4475
Epidermoid carcinomaA-431 
Breast Adenocarcinoma 
MCF7


             





               Human-derived



Tumor type

Cell lines

Acute myeloid leukemia (AML) 
MV4-11 
Acute myeloid leukemia (AML) 
KG-1 
Chronic myelogenous leukemia (CML)K562
Acute myeloblastic leukemia 
Kasumi-1 
CD33+ acute myeloblastic leukemia (AML) 
NAMALWA 
Burkitt's lymphoma (B cell) 
Daudi
Burkitt's lymphoma 
Raji 

 


               Mouse-derived

Colon CarcinomaMC38
Lung Carcinoma 
LLC1 
Breast Carcinoma 
4T1 
Melanoma 
B16-F10 
Hepatoma 
Hepa1-6 


Established CDX models in vivo

BCG No.

Cell NameCancer TypeOrganism
BCG-PS-087-luc 
B-luciferase-GFP Raji Cell Line 
Lymphoma, Burkitt'sHuman
BCG-PS-056-lucB-luciferase-GFP HT-29 Cell LineColorectal adenocarcinomaHuman
BCG-PS-022-lucB-luciferase-GFP H-1975 Cell LineLung carcinoma, non-small cellHuman
BCG-PS-015-luc 
B-luciferase K562 Cell Lin eLeukemia (CML)Human 
BCG-PS-018-luc 
B-luciferase 4T1 Cell Line 
Breast Carcinoma 
Murine
BCG-PS-019-luc 
B-luciferase B16-F10 Cell LineMelanomaMurine
BCG-PS-033-lucB-luciferase MIA PaCa-2 Cell LinePancreatic carcinoma 
Human 
BCG-PS-103-luc
B-luciferase MC38 Cell LineColorectal adenocardinomaMurine
BCG-PS-016-luc 
B-luciferase U-87MG cell line 
GlioblastomaHuman





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Fig 1. In vivo imaging of B-NDG mice 0, 13, and 18 days after tail vein injection with 5x106 Raji-Luc cells.


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Fig 2. In vivo imaging of  C57BL/6  mice 0, 14, and 23 days after tail vein injection with 5x10MC38-Luc cells.


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