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Tumor cells & CDX animals for in vivo imaging

2017-05-25 16:10:38.0

The traditional tumor cells modelCell line-Derived Xenograft, CDX) is a well established model in the research and development process of tumor drugs. The model is easy to establish and has good reproducibility, so it is still largelyin demand for the research and development of tumor drugs. The CDX model is established by inoculating long-term, in vitro passaged tumor cells into immune deficient mice, featuring high homology due to cell homogeneity.


Available services: We provide various cell line tumor models according to the customer’s requirements for research and development, establishment of subcutaneous, orthotopic, or metastatic tumor models. We also provide in vivo pharmacological and pharmacodynamic services for the corresponding models. 

Animal type: Wildtype; immuno-deficient mice.


Established CDX models


Solid tumor cell lines

Tumor type

Cell lines

 Lung carcinoma, non-small cellNCI-H1975
Lung adenocarcinoma
HCC827
Lung Carcinoma
NCI-H520
Lung CarcinomaA549
Lung carcinoma bronchoalveolar
NCI-H1781
Colorectal Ileocecal Adenocarcinoma
HCT-8
Colon CarcinomaHCT-116
Colorectal adenocarcinoma
HT-29
GlioblastomaLN-229
Breast Carcinoma
DU4475
Epidermoid carcinomaA-431
Breast Adenocarcinoma
MCF7
Human-derived


Tumor type

Cell lines

Acute myeloid leukemia (AML)
MV4-11
Acute myeloid leukemia (AML)
KG-1
Chronic myelogenous leukemia (CML)K562
Acute myeloblastic leukemia
Kasumi-1
CD33+ acute myeloblastic leukemia (AML)
NAMALWA
Burkitt's lymphoma (B cell)
Daudi
Burkitt's lymphoma
Raji

Mouse-derived

Colon CarcinomaMC38
Lung Carcinoma
LLC1
Breast Carcinoma
4T1
Melanoma
B16-F10
Hepatoma
Hepa1-6


Established CDX models in vivo


BCG No.

Cell Name Cancer Type Organism
BCG-PS-087-luc
B-luciferase-GFP Raji Cell Line
Lymphoma, Burkitt'sHuman
BCG-PS-056-luc B-luciferase-GFP HT-29 Cell Line Colorectal adenocarcinomaHuman
BCG-PS-022-luc B-luciferase-GFP H-1975 Cell Line Lung carcinoma, non-small cell Human
BCG-PS-015-luc
B-luciferase K562 Cell Lin e Leukemia (CML) Human
BCG-PS-018-luc
B-luciferase 4T1 Cell Line
Breast Carcinoma
Murine
BCG-PS-019-luc
B-luciferase B16-F10 Cell Line Melanoma Murine
BCG-PS-033-luc B-luciferase MIA PaCa-2 Cell Line Pancreatic carcinoma
Human
BCG-PS-103-luc
B-luciferase MC38 Cell Line Colorectal adenocardinomaMurine
BCG-PS-016-luc
B-luciferase U-87MG cell line
GlioblastomaHuman


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Fig 1. In vivo imaging of B-NDG mice 0, 13, and 18 days after tail vein injection with 5x106 Raji-Luc cells.


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Fig 2. In vivo imaging of  C57BL/6  mice 0, 14, and 23 days after tail vein injection with 5x10MC38-Luc cells.


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