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Individualized PDX modeling service based on B-NDG mice

2017-05-25 16:09:49.0

In the last 10 years, the wide application of PDX (Patient-Derived Xenograft) has advanced preclinical evaluations and can forecast the clinical efficacy of tumor drugs. The pharmacodynamic effect of large-scale PDX models on anti-cancer drugs reflects the clinical application result in the patient populations. Therefore, researching the preclinical pharmacodynamic effects of new anti-cancer drugs by using PDX models is helpful for the deeper evaluation and potential clinical applications of new drugs.


Advantages  


  • The  severely immuno-deficient B- NDG mice are more suitable than other immuno-deficient mice for PDX model establishment

  • The tumor model retains the high heterogeneity of tumor tissue, and partial medium compositions of tumor microenvironment are preserved

  • It overcomes the high homology problem of traditional models using tumor cell line cells, and more closely resembles the patient's tumor tissue


Applications


  • The PDX model library  can provide a more in-depth assessment and potential preclinical applications of new drugs

  • It can be used in the preclinical evaluation and forecast clinical efficacy of tumor drugs  

  • It is suitable to study the mechanism of tumorigenesis


PDX model successfully built on the B-NDG mouse (example)



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B-NDG mice show significant PDX model advantages compared to scid mice


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Fig. 1  (A) The gastric sample from a patient was inoculated and formed a subcutaneous tumor on a B-NDG mouse. (B) The tumor growth curve of the patient’s gastric sample in B-NDG mice. (C) Comparing a patient’s gastric sample tumor formation rate between CB17-scid  and B-NDG mice.


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