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B-hPD-1/h4-1BB mice

2017-08-04 14:01:25.0

Strain name: C57BL/6-Pdcd1tm1(hPDCD1)Cd137tm1(hCD137)/Bcgen

Appearance: Black

Related genes: PD-1(Programmed death-1)

                            TNFRSF9(TNF receptor superfamily member 9, also known as 4-1BB)


mRNA expression analysis:

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Fig 1. RT-PCR analysis of 4-1BB gene. The h4-1BB, but not m4-1BB, mRNA was detected in splenocytes of the homozygous B-hPD-1/h4-1BB mice.


Protein expression analysis:

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Fig 2. Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/h4-1BB mice were analyzed by flow cytometry. Mouse 4-1BB+ T cells were detected in the WT C57BL/6 mice, while human 4-1BB+ T cells were detected in the homozygous B-hPD-1/h4-1BB mice.

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Fig 3. Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/h4-1BB mice were analyzed by flow cytometry. Mouse PD-1+ T cells were detected in the WT C57BL/6 mice, while human PD-1+ T cells were detected in the homozygous B-hPD-1/h4-1BB mice.


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