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B-hPD-1/hLAG-3 mice

2017-08-04 14:10:20.0

Strain name: C57BL/6-Pdcd1tm1(hPDCD1)Lag3tm1(hLAG3)/Bcgen

Appearance: Black

Related genes: PD-1(Programmed death-1)

                            LAG-3(Lymphocyte activation gene 3CD223)


Protein expression analysis:

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Fig 1. Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/hLAG-3 mice were analyzed by flow cytometry. Mouse LAG-3+ T cells were detected in both WT C57BL/6 and the homozygous B-hPD-1/hLAG-3 mice, while human LAG-3+ T cells were detected in the homozygous B-hPD-1/hLAG-3 mice. This might result from the cross-recognition of hLAG-3 by anti-mLAG-3 antibodies.


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Fig 2. Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/hLAG-3 mice were analyzed by flow cytometry. Mouse PD-1+ T cells were detected in the WT C57BL/6 mice, while human PD-1+ T cells were detected in the homozygous B-hPD-1/hLAG-3 mice.


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Fig 3. Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/hLAG-3 mice were analyzed by flow cytometry. Mouse PD-1+/LAG-3+ T cells were detected in the WT C57BL/6 mice, while mouse LAG-3+ T cells were detected in the homozygous B-hPD-1/hLAG-3 mice, which might result from the cross-recognition of hLAG-3 by anti-mLAG-3 antibodies.


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Fig 4. Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/hLAG-3 mice were analyzed by flow cytometry. Human PD-1+/LAG-3+ T cells were detected in homozygous B-hPD-1/hLAG-3 mice.




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