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B-hPD-1/hCD27mice

2017-08-04 14:12:43.0

Strain name: C57BL/6-Pdcd1tm1(hPDCD1)Cd27tm1(hCD27)/Bcgen

Appearance: Black

Related genes: PD-1(Programmed death-1)

                            CD27(CD27 molecule)


Protein expression analysis:

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Fig 1. Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/hCD27 mice were analyzed by flow cytometry. Mouse CD27+ T cells were detected in both WT C57BL/6 and the homozygous B-hPD-1/hCD27 mice, while human CD27+ T cells were detected in the homozygous B-hPD-1/hCD27 mice. This might result from the cross-recognition of hCD27 by anti-mCD27 antibodies.


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Fig 2. Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/hCD27 mice were analyzed by flow cytometry. Mouse PD-1+ T cells were detected in the WT C57BL/6 mice, while human PD-1+ T cells were detected in the homozygous B-hPD-1/hCD27 mice.


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