2022 Popular Mouse Models and Cell Lines

2022 Popular Mouse Models and Cell Lines

Biocytogen’s advanced genome editing technologies have been leveraged by our own development scientists to create hundreds of animal and cell models used in biomedical research all over the world.

13 years since our founding, Biocytogen’s catalog of off-the-shelf gene-edited animal models, BioMice, now contains more than 450 strains. From knock-outs to humanized knock-ins, our models are ideal for preclinical evaluation of targeted therapeutics.

If you’re looking for models to accelerate antibody discovery, our fully-human antibody mice, RenMice,can spare critical months and costs. Our highly immunodeficient NDG model and its derivatives are superior for engraftment of human immune cells.

Check out our most popular model and tumor cell Lines list below!

Humanized Immune-Checkpoint Mice

Name Publications & Resources
B-h4-1BB mice Publications: B7-H3×4-1BB bispecific antibody augments antitumor immunity by enhancing terminally differentiated CD8+ tumor-infiltrating lymphocytes

Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist

B-hCD3E mice Publications: The establishment and application of CD3E humanized mice in immunotherapy
B-hCD3EDG mice Webinar: Advancing T cell Therapies Using B-hCD3 Mouse Models
B-hCD40 mice Data package
B-hCD47 mice Publications: Tumor-selective blockade of CD47 signaling with a CD47/PD-L1 bispecific antibody for enhanced anti-tumor activity and limited toxicity

Dose escalation PET imaging for safety and effective therapy dose optimization of a bispecific antibody

B-hPD-1 mice Publications: Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy

Tislelizumab uniquely binds to the CC’ loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage

B-hPD-1/hPD-L1 mice Publications: Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1
B-hPD-1/hPD-L1/h4-1BB mice Data package
B-hPVRIG mice Poster: Humanized PVRIG Mice: A Novel Tool for Evaluating Anti-PVRIG Immunotherapies
B-hSIRPA/hCD47 mice Publications: Preclinical efficacy and toxicity studies of a highly specific chimeric anti-CD47 antibody
B-hTIGIT mice Publications: A novel human anti-TIGIT monoclonal antibody with excellent function in eliciting NK cell-mediated antitumor immunity.
B-hTREM2 mice Data package
B-hVSIG4 mice Poster: Evaluating In Vivo Efficacy of Anti-VSIG4 Antibodies in Humanized B-hVSIG4 Mice 
B-hOX40 mice Data package
B-hLAG3 mice plus Data package


Immunodeficient Mice

B-NDG B2m KO mice plus Poster: Novel Engineered B-NDG B2M KO Mice Plus Shows Delayed GvHD response and Favorable GvL Immune Profiling After hPBMC Engraftment
B-NDG hIL15 mice Poster: B-NDG hIL-15 Mice Improve NK Cell Development After Human PBMC or CD34+ HSC Engraftment


Humanized Cytokine Mice

B-hIL2RA mice Publications: Two novel human anti-CD25 antibodies with antitumor activity inversely related to their affinity and in vitro activity
B-hIL36R mice Poster: Humanized IL36R Mice Provide a Preclinical Tool for the Evaluation of Therapeutic Drugs Targeting IL36R
B-hIL4/hIL4RA mice Publications: The establishment of humanized IL-4/IL-4RA mouse model by gene editing and efficacy evaluation
B-hIL6/hIL6R mice Poster: Humanized IL6/hIL6R mouse model supports the evaluation of therapeutic drug candidates targeting human IL6 and IL6 receptor


Humanized GPCR Mice

B-hCCR8 mice Poster: Humanized CCR8 Mouse Model Provides A Translational Tool For Anti-Human CCR8 Antibody Drug Development


Other Humanized Models

B-hCD38 mice Data package
B-hFcRn mice Publications: IBI112, a selective anti-IL23p19 monoclonal antibody, displays high efficacy in IL-23-induced psoriasiform dermatitis. Int. Immunopharmacol

A single-valent long-acting human CD47 antagonist enhances antibody directed phagocytic activities. Cancer Immunol. Immunother

B-hHER2 mice Data package
B-hPSMA mice Data package


Tumor Cell Lines

B-hPD-L1 MC38 Data package
B-hCD20 MC38 Data package
B-hTROP2 MC38 plus Data package
B-Luc Hep 3B plus Data package


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