AACR 2022

AACR 2022

 


The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.

Poster session:

Humanized models and efficacy studies

Evaluating In Vivo Efficacy of Bi-Functional Fusion Protein Anti-PD-1-IL21 in Humanized B-hIL21R Mice and B-hPD-1/hIL21R Mice

Session Category: Tumor Biology

Poster Number: 1641

 

Evaluating In Vivo Efficacy of Anti-VSIG4 Antibodies in Humanized B-hVSIG4 Mice

Session Category: Tumor Biology

Poster Number: 1642

 

Generation and Validation of Humanized GARP Mice for Testing Novel Anti-Human GARP Antibodies

Session Category: Tumor Biology

Poster Number: 1644

 

Advancing the Development of CD16A-Based Bispecific Antibodies in Humanized CD16A Mouse Models

Session Category: Tumor Biology

Poster Number: 1645

 

Humanized TROP2 Mice Provide a Preclinical Tool for the Evaluation of Therapeutic Drugs Targeting TROP2

Session Category: Tumor Biology

Poster Number: 1646

 

Evaluation of Therapeutic Drug Candidates Using a Novel Humanized B-hCSF1/hCSF1R

Session Category: Tumor Biology

Poster Number: 1648

 

Humanized PVRIG Mice: A Novel Tool for Evaluating Anti-PVRIG Immunotherapies

Session Category: Tumor Biology

Poster Number: 1649

 

Generation of a Novel Humanized TLR8 Mouse Model for the Evaluation of Human TLR8 Agonists and Antibody-Conjugated TLR8 Agonists

Session Category: Tumor Biology

Poster Number: 1651

 

A Humanized Mouse Model of the Promising Immune Checkpoint Molecule B7-H4

Session Category: Tumor Biology

Poster Number: 1652

 

1C3, a Novel Non-blocking Anti-human TNFR2 Antibody Generated From RenMice, Exhibits Promising Anti-tumor Activity and Safety in Syngeneic Tumor Models in Humanized TNFR2 Mice

Session Category: Immunology

Poster Number: 2907

 

Evaluating Delivery of TFR1-targeting Therapies to the CNS in a Novel Humanized TFR1 Mouse Model

Session Category: Experimental and Molecular Therapeutics

Poster Number: 377

 

Preclinical bispecific antibody/ADC candidates 

Generation of TCR-like fully human antibodies against HLA-antigen-peptide complexes using HLA transgenic RenMice

Session Category:  Therapeutic Antibodies

Poster Number: 2885

 

YH012, a Novel Bispecific Anti-HER2 and TROP2 Antibody-Drug Conjugate, Exhibits Potent Antitumor Efficacy

Session Category: Immunology

Poster Number: 4256

 

E-Poster

YH008, a PD-1-CD40 Bispecific Antibody, Inhibits Tumor Growth In Vivo Through PD-1-Dependent Activation of CD40 Signaling

Session Category: Immunology

Poster Number: 5615

 

 Immuno-oncology and Inflammatory/Metabolic Disease Modeling

Developing a Translational Tool for GLP-1-Based Therapeutic Agonists in Humanized GLP1R Mice

Session Category: Prevention/Early Detection/Interception

Poster Number: 3

 

B-hIL12A/hIL12B/hIL12RB1/hIL12RB2: A Novel Animal Model for Generation of IL12 Therapies

Session Category: Tumor Biology

Poster Number: 1643

 

Identifying New Therapeutic Antibodies Using Knockout Mice Expressing Human Immunoglobulin Variable Domain Genes

Session Category: Experimental and Molecular Therapeutics

Poster Number: 1891

 

Evaluating In Vivo Efficacy of Peptide Vaccines in Humanized B-HLA-A2.1 Mice

Session Category: Clinical Research Excluding Trials

Poster Number: 1992

 

Functional Analysis of Anti-TSLP Antibodies Using Humanized B-hTSLP/hTSLPR Mice

Session Category: Immunology

Poster Number: 2089

 

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