Bispecific antibodies (BsAbs) offer unique advantages by targeting two antigens simultaneously, enabling enhanced specificity, overcoming resistance, and addressing disease heterogeneity. They optimize pharmacokinetics, reduce off-target effects, and support diverse mechanisms such as pathway blockade and immune cell redirection, unlocking broad therapeutic potential.
Therapeutic Area | Target(s) | Immunization |
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Preclinical | IND | Status |
oncology | OX40 x CTLA4 (YH006) |
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oncology | 4-1BB xCD40 (BCG021) |
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oncology | CD70xEGFR (BCG020) |
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oncology | CTLA4 X TNFR2 |
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Inflammation and Autoimmunity | 0X40 x 0X40 (BcG028) |
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