RenMab™ Mouse Brochure

RenMab™ Mouse Brochure

Biocytogen has developed a fully human antibody mouse (RenMab™ Mouse), whose genes that encode entire antibody variable regions are replace in situ by human Ig heavy chain and κ light chain through Mb-scale chromosome engineering technology. RenMab™ Mouse provides an efficient platform for fully human antibody generation, characterization, therapeutic antibody discovery, and rapid in vivo efficacy screening.

Highlights of RenMab™ Mouse:

  • An intact immune system compared to wild-type mouse
  • Full human VDJ expression in the variable domains of heavy chain and kappa light chain genes
  • Fully human antibody repertoire as shown by CDR3 analysis
  • Highly similar immune responses compared to wild-type mouse

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