RenMab™ Technical Data Sheet

RenMab™ Technical Data Sheet

Biocytogen has developed a fully human antibody mouse (RenMab™ Mouse), whose genes that encode entire antibody variable regions are replace in situ by human Ig heavy chain and κ light chain through Mb-scale chromosome engineering technology. RenMab™ Mouse provides an efficient platform for fully human antibody generation, characterization, therapeutic antibody discovery, and rapid in vivo efficacy screening.

Highlights of RenMab™ Mouse:

  • Developed using Biocytogen’s unique Mb-scale chromosome engineering technology
  • Variable regions of mouse heavy chain are and k light chain genes are replaced by human counterparts in situ
  • Constant region is retained to ensure proper B cell development
  • Normal immune organs development and good immune response to immunization like WT mouse
  • RenMab antibodies exhibit human-like repertoire and high affinity to antigens in subnanomolar range

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