First Half of 2022 Publications Highlight

Our off-the-shelf and custom animal and cell models are advancing cutting-edge biomedical research every day. One measure of this impact is how often they appear in high impact publications and journals. Check out the list of studies published so far this year which feature Biocytogen models:

B-hCD3E Mice

Zhang, R., Zhang, J., Zhou, X. et al. The establishment and application of CD3E humanized mice in immunotherapy. Exp Anim. (2022). https://doi.org/10.1538/expanim.22-0012

B-hPD-1 Mice

Huang, J., Liu, D., Wang, Y. et al. Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy. Gut. (2021). http://dx.doi.org/10.1136/gutjnl-2020-321031

Immunodeficient B-NDG Mice

Mei, Z., Yang, T., Liu, Y. et al. Management of prostate cancer by targeting 3βHSD1 after enzalutamide and abiraterone treatment. Cell Rep Med. (2022). https://doi.org/10.1016/j.xcrm.2022.100608

Huang, C.-S., Zhu, Y.-Q., Xu, Q.-C. et al. YTHDF2 promotes intrahepatic cholangiocarcinoma progression and desensitises cisplatin treatment by increasing CDKN1B mRNA degradation. Clin Transl Med. (2022). https://doi.org/10.1002/ctm2.848

Shen, Y., Lu, C., Song, Z. et al. Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediated TGF-β degradation. Nat Commun. (2022). https://doi.org/10.1038/s41467-022-31141-6

RenMab Mice

Chai, M., Guo, Y., Yang, L. et al. A high-throughput single cell-based antibody discovery approach against the full-length SARS-CoV-2 spike protein suggests a lack of neutralizing antibodies targeting the highly conserved S2 domain. Brief Bioinform. (2022). https://doi.org/10.1093/bib/bbac070

B-hCTLA4 Mice

Sato, Y., Casson, C.N., Matsuda, A. et al. Fc-independent functions of anti-CTLA-4 antibodies contribute to anti-tumor efficacy. Cancer Immunol Immunother. (2022). https://doi.org/10.1007/s00262-022-03170-z

B-hPD-L1/h4-1BB Mice

Muik, A., Garralda, E., Altintas, I. et al. Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors. Cancer Discov. (2022). https://doi.org/10.1158/2159-8290.CD-21-1345

B-hTNFR2 Mice

Chen, Y., Jia, M., Wang, S. et al. Antagonistic Antibody Targeting TNFR2 Inhibits Regulatory T Cell Function to Promote Anti-Tumor Activity. Front Immunol. (2022). https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.835690/full

B-hSTING Mice

Ulrich-Lewis, J.T., Draves, K.E., Roe, K. et al. STING Is Required in Conventional Dendritic Cells for DNA Vaccine Induction of Type I T Helper Cell-Dependent Antibody Responses. Front Immunol. (2022). https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.861710/full

B-Il17a-EGFP Mice

Hu, B., Wang, H., Xiao, F. E74 Like ETS Transcription Factor 3 is a Negative Regulator of Pathogenic Lamina Propria T Helper 17.1 Cells in Murine Colitis. Immunol Invest. (2022). https://doi.org/10.1080/08820139.2022.2084409

Efficacy and Toxicity Studies

Jiang, F., Shen, J., Cheng, J. et al. N-terminal signal peptides facilitate the engineering of PVC complex as a potent protein delivery system. Sci Adv. (2022). https://doi.org/10.1126/sciadv.abm2343

Gene Editing Services

Hou, S., Li, Z., Dong, J. et al. Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals. https://doi.org/10.1038/s41422-022-00615-z

Liu, C., Xiong, Q., Li, Q. et al. CHD7 regulates bone-fat balance by suppressing PPAR-γ signaling. Nat Commun. (2022). https://doi.org/10.1038/s41467-022-29633-6

Li, S.L., Wang, Z.M., Xu, C. et al. Liraglutide Attenuates Hepatic Ischemia-Reperfusion Injury by Modulating Macrophage Polarization. Front Immunol. (2022). https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.869050/full

Liu, C., Zhou, M., Jiang, W. et al. GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils. Front Immunol. (2022). https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.870183/full

Li, S., Zhu, Q., Cai, Y. et al. Generation of an induced pluripotent stem cell line from a patient with Angelman syndrome carrying UBE3A mutation. Stem Cell Res. (2022).

Xiong, X., Chen, S., Shen, J. et al. Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2. Sig Transduct Target Ther. (2022). https://doi.org/10.1038/s41392-022-00918-y

Li, J., Sun, X., You, Y. et al. Auts2 deletion involves in DG hypoplasia and social recognition deficit: The developmental and neural circuit mechanisms. Sci Adv. (2022).

Wang, T., Xia, C., Weng, Q. et al. Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway. Haematologica. (2022). https://doi.org/10.3324/haematol.2019.239186

Jiang, K., Xu, Y., Wang, D. et al. Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis. Protein Cell. (2022). https://doi.org/10.1007/s13238-020-00809-4

Liu, N., Tang, J., Xue, Y. et al. EP3 Receptor Deficiency Improves Vascular Remodeling and Cognitive Impairment in Cerebral Small Vessel Disease. Aging Dis. (2022).

Qian, L.L., Ji, J.J., Jiang, Y. et al. Serpina3c deficiency induced necroptosis promotes non-alcoholic fatty liver disease through β-catenin/Foxo1/TLR4 signaling. FASEB J. (2022).

Zhang, Y., Ye, Y., Tang, X. et al. CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure. J Exp Med. (2022). https://doi.org/10.1084/jem.20200418

Dong, Z., Ma, Z., Yang, M. et al. The Level of Histone Deacetylase 4 is Associated with Aging Cartilage Degeneration and Chondrocyte Hypertrophy. J Inflamm Res. (2022).

Cui, H.-Y., Wei, W., Qian, M.-R. et al. PDGFA-associated protein 1 is a novel target of c-Myc and contributes to colorectal cancer initiation and progression. Cancer Commun (Lond). (2022).

Tian, C., Chai, J., Liu, W. et al. Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis. Front Physiol. (2022). https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.923185/full

Patel, P., Buchanan, C.N., Zdradzinski, M.D. et al. Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs. Nucleic Acids Res. (2022).

Wang, J., Gong, J., Wang, Q. et al. VDAC1 negatively regulates melanogenesis through the Ca2+ – calcineurin-CRTC1-MITF pathway. Life Sci Alliance. (2022). https://doi.org/10.26508/lsa.202101350