Rat Gene Editing

Although mice are the most commonly used mammalian experimental animal model, rat disease models offers many advantages over the mouse and other organisms. 

The physiology of diseased rat models not only resembles more closely to humans but also comparatively easier to monitor in rats than mice. Popular experimental rat strains include sprague dawley, Wistar, and F344. Biocytogen uses CRISPR/Cas9-based EGE™ to generate gene knockout and knockin rats.

Application Example:

The First Reporter Rat Developed by Biocytogen in 2014

As shown below, a pCAG-loxP-3X STOP-loxP-tdTomato-WPRE-bGHpA cassette is inserted between the first and second exons of the Rosa26 site using EGE™ technology. After mating cKI rats with Crh-Cre rats, tdTomato is highly expressed in the hippocampus of the Crh-Cre/tdTomato offspring.

Cre Rat Models List

Product Product No Application Fields
B-3XGFP cKI Rats B-CR-017 Cre-induced GFP expression, for Cre expression profile detection
B-ALB-CreERT2 Rats B-CR-019 Alb promoter-driven inducible Cre rat model (Liver)
B-Camk2a-Cre Rats B-CR-001 Camk2a promoter-driven Cre rat model (Cortex, frontal lobe)
B-Drd1-Cre Rats B-CR-002 Drd1 promoter-driven Cre rat model (nucleus accumbens, dorsal striatum)
B-Drd2-Cre Rats B-CR-003 Drd2 promoter-driven Cre rat model (nucleus accumbens, dorsal striatum, pituitary)
B-Kit-CreERT2 Rats B-CR-004 Kit promoter-driven inducible Cre rat model (lung, cerebellum)
B-Myh6-CreERT2 Rats B-CR-018 Myh6 promoter-driven inducible Cre rat model (Heart)
B-Nphs2 (podocin)-CreERT2 Rats B-CR-005 Nphs2 promoter-driven inducible Cre rat model (Kidney)
B-Slc6a2-Cre Rats B-CR-007 Slc6a2 promoter-driven Cre rat model (Noradrenergic neuron)
B-Slc6a3 (Dat1)-Cre Rats B-CR-008 Slc6a3 promoter-driven Cre rat model (Dopaminergic neurons)
B-Sncg (Synuclein,Gamma)-Cre Rats B-CR-009 Sncg promoter-driven Cre rat model (dorsal striatum)
B-Tdtomato cKI Rats B-CR-011 Cre-induced GFP expression, for Cre expression profile detection

Other Genetically Modified Rat Models

Product Product No Description and Application
B-Apoe KO Rats B-TR-006 Cardiovascular system (hyperlipidemia, atherosclerosis)
B-Il2rg-KO Rats B-TR-003 Immune system (Immunodeficiency)
B-Ldlr-KO rats B-TR-004 Cardiovascular system (Hyperlipidemia, atherosclerosis)
B-Pink1 KO Rats B-CR-014 Parkinson disease model
B-Rag2 KO Rats B-TR-007 Immune system (Immunodeficiency)
B-Rag2-IL2rgKO Rats B-TR-008 Immune system (Immunodeficiency)
B-Tp53-KO Rats B-TR-005 Tumor formation, drug detection
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