Cre (ERT2) Knockin

Cre (ERT2) Knockin

Cre (ERT2) Inducible Mouse Model

The Cre recombinase protein mediates a tissue specific deletion of DNA fragments that are flanked by loxP sites. Therefore, the Cre mouse model allows tissue specific gene knockout based on the promoter driving Cre expression. The ERT2 sequence is an estrogen receptor targeting motif, whose nuclear translocation and activity are controlled by Tamoxifen. Thus, tamoxifen administration enables temporal or inducible control of Cre activity and gene deletion.