Humanized animal models are developed using genetic engineering techniques to integrate human genes into the animal genome, enabling the expression of human genes or proteins. These models are extensively used to study gene function, replicate the mechanisms and progression of human diseases, and evaluate the efficacy and safety of therapeutic drugs. Among these models, mice are particularly well-suited for studying human gene function and disease due to their significant similarity to humans in terms of gene number and functional characteristics.
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Biocytogen utilizing advanced gene-editing technologies to modify specific gene loci in mice while keeping other genes and physiological systems unchanged. This approach allows for precise investigation into the functions of specific human genes and their roles in diseases. The related animal models cover areas such as oncology, autoimmune diseases, metabolism, and neurology. Leveraging their extensive experience in animal model development, they design detailed and scientifically rigorous strategies by carefully considering all factors that could potentially influence gene expression. This ensures the stability and reliability of gene expression, significantly enhancing the stability of the models.
BALB/cCrSIcNifdc-Tnfrsf9tm1(TNFRSF9)Bcgen/Bcgen • 112652
C57BL/6-Fcgr4tm2(FCGR3A)Bcgen/Bcgen • 111173
C57BL/6-Cd3etm1(CD3E)Bcgen Cd3dtm1(CD3D)Bcgen Cd3gtm1(CD3G)Bcgen/Bcgen • 110039
C57BL/6-Fcgrttm1(FCGRT)Bcgen/Bcgen • 110001
C57BL/6JNifdc-Glp1rtm3(GLP1R)Bcgen/Bcgen • 113033
C57BL/6-Il4tm2(IL4)BcgenIl4ratm1(IL4RA)Bcgen/Bcgen • 120551
C57BL/6JNifdc-B2mtm1(B2M/HLA-A11.1/H2-D)Bcgen/Bcgen • 112803
C57BL/6-Tfrctm1(TFRC)Bcgen/Bcgen • 110861
C57BL/6N-Tg(CH17-302I14)1Bcgen,Siglecetm1Bcgen/Bcgen • 112767
