animal models & cell lines

Immunodeficient Models

Humanized immunodeficient mice offer a versatile model for the assessment of human-based immunotherapies. Our team at Biocytogen independently designed and generated the severely immunodeficient B-NDG mouse model (NOD.CB17-Prkdcscid Il2rgtm1Bcgen/Bcgen). B-NDG mice lack mature T cells, B cells, functional NK cells, and display cytokine signaling deficiencies. These collective properties render B-NDG mice with the highest degree of immunodeficiency, making B-NDG mice most suitable for engraftment and growth of human hematopoietic stem cells (HSCs), peripheral blood mononuclear cells (PBMCs), and human tumor cells/tissues. Based on the B-NDG mice, Biocytogen has also developed a series of second-generation mice tailored for different applications.

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  • Key Features of Biocytogen's Immunodeficient Models
  • Featured Products
  • Product List
Key Features of Biocytogen's Immunodeficient Models
  • Model currently holds the highest degree of immunodeficiency among all immunodeficiency models 
  • Longer lifespan than NOD-scid or NSG mice; 1.5 years on average 
  • Minimal to absent rejection of human-derived cells and tissues 
  • More efficient for CDX model generation 
  • No B lymphocyte leakage 
  • To address immune system reconstruction challenges in severely immunodeficient mice, Biocytogen developed second-generation models based on B-NDG. These models support diverse preclinical studies in tumor immunotherapy.
Featured Products
Product List
    Immunodeficient Models
    Product Name Product No. Background Actions
    B-Fcgr4 KO mice(CB-17 SCID) 111654 CB-17 SCID
    B-hCD16A mice plus(CB-17 SCID) 113688 CB-17 SCID
    B-hCD16A mice(CB-17 SCID) 111174 CB-17 SCID
    B-hCD16A/hNKP46 mice(CB-17 SCID) 112987 CB-17 SCID
    B-hCD98HC/Rag2 KO mice 112326 C57BL/6N
    B-hFcRn, Rag2 KO mice 113288 C57BL/6
    B-hNKP46 mice(CB-17 SCID) 112259 CB-17 SCID
    B-hPSGL-1, Rag2 KO mice 114033 C57BL/6N
    B-hTFR1, Rag2 KO mice 112904 C57BL/6
    B-hTL1A, Rag2 KO mice 114011 C57BL/6N
    B-Il2rg KO rats 210513 SD
    B-NDG B2m KO mice plus 110601 B-NDG
    B-NDG B2m plus/hIL15 mice 111856 B-NDG
    B-NDG FcγR KO mice 112839 B-NDG
    B-NDG Flt3 KO mice 112869 B-NDG
    B-NDG H2-Ab1 KO mice 110595 B-NDG
    B-NDG H2-K1/H2-D1 KO mice 112256 B-NDG
    B-NDG hairless mice 110598 B-NDG
    B-NDG hALB mice 111982 B-NDG
    B-NDG hALB/hFcRn mice 112774 B-NDG
    B-NDG hB2M/HLA-A11.1 mice 112451 B-NDG
    B-NDG hB2M/HLA-A11.1 mice plus 112474 B-NDG
    B-NDG hB2M/HLA-A2.1 mice plus 112449 B-NDG
    B-NDG hB2M/HLA-A24.2 mice 112560 B-NDG
    B-NDG hB2M/HLA-A24.2 mice plus 112874 B-NDG
    B-NDG hB2M/HLA-A3.1 mice 112450 B-NDG
    B-NDG hB2M/HLA-A3.1 mice plus 112873 B-NDG
    B-NDG Hc mice 110605 B-NDG
    B-NDG hCSF1 mice 110591 B-NDG
    B-NDG hCSF1/hTHPO mice 120609 B-NDG
    B-NDG hEPCAM mice 112660 B-NDG
    B-NDG hF3 mice 113228 B-NDG
    B-NDG hFcRn mice 111922 B-NDG
    B-NDG hFLT3LG, Flt3 KO mice 112889 B-NDG
    B-NDG hGM-CSF mice 110593 B-NDG
    B-NDG hGPC3 mice 113231 NOD
    B-NDG hHER3 mice 113220 B-NDG
    B-NDG hIL15 mice 110600 B-NDG
    B-NDG hIL15, FcγR KO mice 112653 B-NDG
    B-NDG hIL2 mice 113385 B-NDG
    B-NDG hIL6 mice 110596 B-NDG
    B-NDG hIL7 mice 110597 B-NDG
    B-NDG hIL7/hIL15 mice 120612 B-NDG
    B-NDG HLA-A2.1 mice 110599 B-NDG
    B-NDG hSIRPA mice 110604 B-NDG
    B-NDG hSIRPA/hCD47 mice 110603 B-NDG
    B-NDG hTHPO mice 110590 B-NDG
    B-NDG hTHPO/hSCF mice 113801 NOD
    B-NDG hTROP2 mice 113178 B-NDG
    B-NDG Kit W41 mice 112914 B-NDG
    B-NDG MGMT3 mice 111882 B-NDG
    B-NDG MHC I/II DKO mice plus 111895 B-NDG
    B-NDG MHC I/II DKO/hMSLN mice 112704 B-NDG
    B-NDG mice 110586 NOD scid
    B-NDG nude mice 110587 B-NDG
    B-NDG Tg(RORγt-Il2rg) mice 112590 B-NDG
    B-nude rats 112457 SD
    B-Rag2 KO mice 110809 C57BL/6N
    B-Rag2 KO mice(C) 112883 BALB/cCrSlcNifdc
    B-Rag2 KO rats 210511 SD
    B-Rag2/F8 DKO mice 112250 C57BL/6
    B-Rag2/Il2rg DKO mice 112937 C57BL/6N
    B-SDG rats 210512 SD
    huHSC-B-NDG hCSF1/hTHPO mice 112863 B-NDG
    huHSC-B-NDG hIL15 mice 112478 B-NDG
    huHSC-B-NDG hIL15, FcγR KO mice 114031 B-NDG
    huHSC-B-NDG hIL6 mice 112864 B-NDG
    huHSC-B-NDG HLA-A2.1 mice 112865 B-NDG
    huHSC-B-NDG hTHPO mice 112480 B-NDG
    huHSC-B-NDG MGMT3 mice 112479 B-NDG
    huHSC-B-NDG mice 112470 NOD scid
    huNK-B-NDG hIL15 mice 112482 B-NDG
    huPBMC-B-NDG B2m KO mice plus 112484 B-NDG
    huPBMC-B-NDG MHC I/II DKO mice plus 112483 B-NDG
    huPBMC-B-NDG mice 112469 NOD scid