AACR 2023: Development of Immunodeficient Mice Expressing Human IL3, GM-CSF, CSF1 and THPO for Improved Human Myeloid and Lymphoid Cell Reconstitution
Used in the poster: B-NDG MGMT3 mice Conclusions We generated an immunodeficient (B-NDG) mouse model containing human GM-CSF, CSF1, THPO, and IL3 in place of…
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AACR 2023: Identification of DM004, A First-In-Class Anti-5T4/MET Bispecific Antibody-Drug Conjugate
Conclusions DM004's parental 5T4 ADC shows excellent anti-tumor efficacy both in vitro and in vivo. The reduced binding avidity of anti-MET monovalent antibodies suggests improved…
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AACR 2023: A First-In-Class Bispecific Antibody-Drug Conjugate (DM002) Targeting HER3 and the Juxtamembrane Domain of MUC1
Conclusions HER3 and MUC1 are co-expressed in a variety of solid tumors, especially those with the highest mortality. DM002 is a novel fully human bispecific…
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AACR 2023: A First-In-Class Anti-TROP2/EGFR Bispecific Antibody-Drug Conjugate, DM001, Exhibits Potent Anti-Tumor Efficacy
Conclusions In vitro efficacy of DM001： DM001 showed high affinity and cytotoxicity in multiple TROP2+ EGFR+ cancer cell lines. DM001 delayed cell cycle progression and…
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AACR 2023: Discovery of BCG033, A Novel Anti-PTK7 x TROP2 Bispecific Antibody-Drug Conjugate with Promising Efficacy Against Triple-Negative Breast Cancer
Conclusions BCG033 is a novel and fully human bispecific PTK7 and TROP2 antibody-drug conjugate generated from the RenLite® platform. Cytotoxicity assays and internalization assays indicate…
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AACR 2023: BCG022: A Novel Bispecific Antibody-Drug Conjugate Targeting HER3 and MET
Conclusions BCG022 is a novel and fully human bispecific antibody-drug conjugate generated from the RenLite® platform that exhibits cross-species reactivity to human and cynomolgus monkey…
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AACR 2023: A First-In-Class Anti-HER2/TROP2 Bispecific Antibody-Drug Conjugate (YH012) Exhibits Potent Anti-Tumor Efficacy
Conclusions HER2 and TROP2 are co-expressed in a wide range of tumor types. Of note, TROP2 was also expressed in many HER2-low solid tumors, such…
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AACR 2023: Discovery of RenNano®-Derived Human Heavy-Chain-Only Antibodies That Cross the Blood-Brain-Barrier
Used in the poster: RenNano® platform Conclusions TFR1-targeting HCAbs developed from RenNano® mice have high affinity to human TFR1, and have functional capabilities, including internalization capacity.…
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AACR 2023: RenNano® Mice: A Heavy-Chain-Only Antibody Platform for the Generation of Nanobody Therapeutics
Used in the poster: RenNano® platform Conclusions RenNano® mice contain all human V,D, and J genes in situ with a modified murine constant region designed…
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AACR 2023: In vivo Efficacy of an Anti-Human IL11RA Antibody in B-hIL11RA Mice With APAP-Induced Liver Damage
Used in this poster: B-hIL11RA mice Conclusions mRNA expression analysis: Murine Il11ra1 mRNA was detected in liver tissue isolated from wild-type C57BL/6 (+/+) mice, while…
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