ASCO 2022: A phase I open-label dose escalation of YH003 (CD40 mAb) in combination with toripalimab (PD-1 mAb) in patients with advanced solid tumors
YH003, a recombinant, humanized agonistic anti-CD40 IgG2 monoclonal antibody (mAb) specifically recognizes and agonizes CD40 on the antigen-presenting cells to enhance immune responses. Preclinical data…
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ASCO 2022: A first-in-human phase I dose escalation of YH001 (CTLA-4 mAb) in combination with PD-1 mAb in patients with advanced solid tumors
YH001 is a humanized anti-hCTLA-4 IgG1 mAb that relieves CTLA-4-mediated immunosuppression, and thereby enhances the T-cell-mediated antitumor immune response. Pre-clinical data have shown potent anti-cancer…
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AACR 2022: YH012, a Novel Bispecific Anti-HER2 and TROP2 Antibody-Drug Conjugate, Exhibits Potent Antitumor Efficacy
Conclusions YH012 is a novel bispecific HER2/TROP2 antibody-drug conjugate (BsAb-ADC) developed using the RenLiteTM platform. The TAAs HER2 and TROP2 are highly co-expressed in a…
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AACR 2022: Generation of TCR-like fully human antibodies against HLA-antigen-peptide complexes using HLA transgenic RenMice
Conclusions We describe an HLA transgenic mouse that acquires fully human TCR mimic antibodies through a proprietary immunization procedure. Beacon on-chips screening and high-throughput binding…
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AACR 2022: 1C3, a Novel Non-blocking Anti-human TNFR2 Antibody Generated From RenMice, Exhibits Promising Anti-tumor Activity and Safety in Syngeneic Tumor Models in Humanized TNFR2 Mice
Conclusions An anti-TNFR2 antibody, 1C3, was obtained via unbiased screening by detecting efficacy using humanized mice. 1C3 binds to the CRD3 AND CRD4 domains of…
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AACR 2022: Advancing the Development of CD16A-Based Bispecific Antibodies in Humanized CD16A Mouse Models
Conclusions Human CD16A expression was confirmed in homozygous B-hCD16A mice by RT-PCR and flow cytometry. Similar proportions of splenic immune cells were observed between humanized…
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AACR 2022: Generation of a Novel Humanized TLR8 Mouse Model for the Evaluation of Human TLR8 Agonists and Antibody-Conjugated TLR8 Agonists
Conclusions mRNA expression analysis: Mouse Tlr8 mRNA was detectable in wild-type C57BL/6 mice (+/+). Human TLR8 mRNA was detectable only in heterozygote B-hTLR8 but not…
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AACR 2022: A Humanized Mouse Model of the Promising Immune Checkpoint Molecule B7-H4
Conclusions As a negative regulator of T cell responses that is highly expressed in a range of carcinoma types, B7-H4 has emerged in recent years…
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AACR 2022: Functional Analysis of Anti-TSLP Antibodies Using Humanized B-hTSLP/hTSLPR Mice
Conclusions • TSLP and TSLPR protein expression analysis: Human TSLP and TSLPR protein was exclusively detected in humanized B-hTSLP/hTSLPR mice compared to wild-type mice by…
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AACR 2022: Humanized PVRIG Mice: A Novel Tool for Evaluating Anti-PVRIG Immunotherapies
Conclusions mRNA gene expression analysis by RT-PCR: Murine Pvrig mRNA was detected in splenocytes isolated from wild-type C57BL/6 (+/+) mice, while human PVRIG mRNA was…
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