AACR 2021: Humanized IL6/hIL6R mouse model supports the evaluation of therapeutic drug candidates targeting human IL6 and IL6 receptor

AACR 2021: Humanized IL6/hIL6R mouse model supports the evaluation of therapeutic drug candidates targeting human IL6 and IL6 receptor

Author: Leila Kokabee, Yichao Chen, Linlin Wang, Xiaohan Zhang, Xiaofei Zhou, Qingcong Lin, Zhaoxue (Luke) Yu

  • Interleukin 6 (IL-6) is a pleiotropic cytokine that not only plays an important role in the immune response, but has also been associated with the development of autoimmune diseases via chronic inflammation. 
  • Biocytogen generated a double humanized B-hIL6/hIL6R mouse model by replacing the mouse full-length and protein coding sequences of Il6 and Il6r, respectively, with the corresponding human sequences. 
  • Collagen induced arthritis (CIA) was modeled in B-hIL6/hIL6R mice to evaluate the in vivo efficacy of anti-human IL6 antibodies. 
  • Anti-human IL6 antibody treatment reversed CIA disease progression in B-hIL6/hIL6R mice by decreasing the total clinical score.
  • B-hIL6/hIL6R mice are a promising model for in vivo efficacy evaluation of IL6 and IL6R antibodies. 

 

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