AACR 2022: Generation and Validation of Humanized GARP Mice for Testing Novel Anti-Human GARP Antibodies

AACR 2022: Generation and Validation of Humanized GARP Mice for Testing Novel Anti-Human GARP Antibodies

Conclusions

  • We have generated a humanized mouse model expressing GARP in place of the murine counterpart.
  • mRNA and protein expression of human GARP indicates successful generation of the humanized model.
  • Humanization of GARP does not change the overall development, differentiation or distribution of immune cell types, CBC profile, or liver chemistry in mice.
  • Anti-GARP antibody treatment reduced tumor growth in B-hGARP mice in combination with anti-mouse PD-1, indicating that B-hGARP mice provide a powerful model for in vivo evaluation of novel combination therapies.

Related mouse model: B-hGARP mice

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