AACR 2022: Humanized IL36R Mice Provide a Preclinical Tool for the Evaluation of Therapeutic Drugs Targeting IL36R

AACR 2022: Humanized IL36R Mice Provide a Preclinical Tool for the Evaluation of Therapeutic Drugs Targeting IL36R

Conclusions

  • We have generated a humanized mouse model expressing IL36R in place of the murine counterpart.
  • mRNA and protein expression of human IL36R indicates successful generation of the humanized model.
  • Humanization of IL36R does not change the overall development, differentiation or distribution of immune cell types in spleen, lymph node and blood.
  • The anti-IL36R antibody Spesolimab analog reduced psoriasis-like skin lesions in B-hIL36R mice, indicating that B-hIL36R mice provide a powerful model for in vivo evaluation of anti-human IL36R antibodies.

Related mouse model: B-hIL36R mice

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