AACR 2023: BCG008, A Human Siglec-15 Blocking Antibody, Displays Potent Anti-Tumor Activity in Siglec-15-Humanized Mice

AACR 2023: BCG008, A Human Siglec-15 Blocking Antibody, Displays Potent Anti-Tumor Activity in Siglec-15-Humanized Mice

Conclusions

• BCG008 is a novel, fully human anti-SIGLEC-15 antibody generated from RenMab^TM mice
• BCG008 has higher hSIGLEC-15 & fasSIGLEC-15 affinity and recognizes a different epitope than 5G12
• BCG008 reverses SIGLEC-15 mediated T cell suppression in a dose-dependent manner
• BCG008 has a longer half-life than 5G12 (9.79 days vs. 4.19 days)
• BCG008 has strong antitumor efficacy and a good safety profile in vivo