AACR 2023: Development of MHC I/II Knock-Out Immunodeficient Mouse Strains for Alleviating GvHD Induced by Human PBMC Reconstitution
Used in the poster: B-NDG MHC I/II DKO mice plus
- We have generated an immunodeficient model, B-NDG MHC I/II DKO mice plus, that lacks both MHC-I and MHC-II.
- Protein expression analysis confirms that B-NDG MHC I/II DKO mice plus lack Mouse H-2Kb/H-2Db and Mouse I-Ak.
- B-NDG MHC I/II DKO mice plus mice displayed an extended life span and reduced GvHD following human PBMC engraftment when compared to B-NDG mice and B-NDG B2m KO mice plus.
- B-NDG MHC I/II DKO mice plus is an ideal immunodeficient model for extended engraftment of human PBMCs.