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    AACR 2023: Humanized OX40/OX40L Mice as a Tool for Evaluating Novel Therapeutics

    April 18, 2023
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    Conclusions

    mRNA expression analysis:

    Mouse Ox40l mRNA was detected in dendritic cells isolated from wild-type mice, while human OX40L mRNA was detected in homozygous B-hOX40/hOX40L mice by RT-PCR. Protein expression analysis:

    Human OX40 and OX40L protein expression was detected in B-hOX40/hOX40L mice by flow cytometry. Immune cell analysis:

    OX40 and OX40L humanization does not change the overall development, differentiation or distribution of spleen, lymph node, and blood immune cells in B-hOX40/hOX40L mice.