AACR 2023: In vivo Efficacy Evaluation of Anti-Human VEGFR2 Antibodies in Humanized B-hVEGFR2 Mice
Used in the poster: B-hVEGFR2 mice
Conclusions
- mRNA expression analysis:
Murine Vegfr2 mRNA was detected in embryonic tissue isolated from wild-type mice, while human VEGFR2 mRNA was detected in B-hVEGFR2 mice. - Protein expression analysis:
Murine VEGFR2 protein was detected in wild-type mice, while human VEGFR2 protein was detected in B-hVEGFR2 mice. - In vivo efficacy:
Anti-human VEGFR2 antibody was effective in controlling MC38 tumor growth in B-hVEGFR2 mice and inhibits vascular endothelial cell proliferation.
