AACR 2023: In vivo Efficacy Evaluation of Anti-Human VEGFR2 Antibodies in Humanized B-hVEGFR2 Mice

Used in the poster: B-hVEGFR2 mice

Conclusions

mRNA expression analysis:
Murine Vegfr2 mRNA was detected in embryonic tissue isolated from wild-type mice, while human VEGFR2 mRNA was detected in B-hVEGFR2 mice.
Protein expression analysis:
Murine VEGFR2 protein was detected in wild-type mice, while human VEGFR2 protein was detected in B-hVEGFR2 mice.
In vivo efficacy:
Anti-human VEGFR2 antibody was effective in controlling MC38 tumor growth in B-hVEGFR2 mice and inhibits vascular endothelial cell proliferation.

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