mRNA expression analysis:

Murine Vegfr2 mRNA was detected in embryonic tissue isolated from wild-type mice, while human VEGFR2 mRNA was detected in B-hVEGFR2 mice. Protein expression analysis:

Murine VEGFR2 protein was detected in wild-type mice, while human VEGFR2 protein was detected in B-hVEGFR2 mice. In vivo efficacy:

Anti-human VEGFR2 antibody was effective in controlling MC38 tumor growth in B-hVEGFR2 mice and inhibits vascular endothelial cell proliferation.