AACR 2023: In vivo Efficacy of an Anti-Human IL11RA Antibody in B-hIL11RA Mice With APAP-Induced Liver Damage
Used in this poster: B-hIL11RA mice
Conclusions
- mRNA expression analysis:
Murine Il11ra1 mRNA was detected in liver tissue isolated from wild-type C57BL/6 (+/+) mice, while human IL11RA mRNA was detected in homozygous B-hIL11RA (H/H) mice. - Protein expression analysis:
IL11RA protein was detected in the liver from wild-type and B-hIL11RA mice. - In vivo efficacy:
Anti-human IL11RA antibody alleviated APAP-induced liver damage in humanized B-hIL11RA mice.
