AACR 2023: In vivo Efficacy of an Anti-Human IL11RA Antibody in B-hIL11RA Mice With APAP-Induced Liver Damage

AACR 2023: In vivo Efficacy of an Anti-Human IL11RA Antibody in B-hIL11RA Mice With APAP-Induced Liver Damage

Used in this poster: B-hIL11RA mice

Conclusions

  • mRNA expression analysis:
    Murine Il11ra1 mRNA was detected in liver tissue isolated from wild-type C57BL/6 (+/+) mice, while human IL11RA mRNA was detected in homozygous B-hIL11RA (H/H) mice.
  • Protein expression analysis:
    IL11RA protein was detected in the liver from wild-type and B-hIL11RA mice.
  • In vivo efficacy:
    Anti-human IL11RA antibody alleviated APAP-induced liver damage in humanized B-hIL11RA mice.

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