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    AACR 2023: In vivo Efficacy of an Anti-Human IL11RA Antibody in B-hIL11RA Mice With APAP-Induced Liver Damage

    April 18, 2023
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    Conclusions


    mRNA expression analysis:

    Murine Il11ra1 mRNA was detected in liver tissue isolated from wild-type C57BL/6 (+/+) mice, while human IL11RA mRNA was detected in homozygous B-hIL11RA (H/H) mice.


    Protein expression analysis:

    IL11RA protein was detected in the liver from wild-type and B-hIL11RA mice.


    In vivo efficacy:

    Anti-human IL11RA antibody alleviated APAP-induced liver damage in humanized B-hIL11RA mice.