mRNA expression analysis:
Murine Il11ra1 mRNA was detected in liver tissue isolated from wild-type C57BL/6 (+/+) mice, while human IL11RA mRNA was detected in homozygous B-hIL11RA (H/H) mice.
IL11RA protein was detected in the liver from wild-type and B-hIL11RA mice.
Anti-human IL11RA antibody alleviated APAP-induced liver damage in humanized B-hIL11RA mice.