AACR 2024: BCG017, a bispecific ADC targeting PTK7 and EGFR exhibits anti-tumor efficacy in PDX models
Used in the poster: Bispecific ADC Platform Summary: A bispecific antibody-drug conjugate (bsADC), BCG017-vcMMAE, targeting both PTK7 and EGFR demonstrated potent anti-tumor activity in various…
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AACR 2024: Identification of fully human CCR8 antibodies that demonstrate excellent ADCC function, potent blocking activity, and robust anti-tumor immune responses
Used in the poster: RenMabTM mice Summary: Immune checkpoint blockade therapy (ICT) is effective against tumors, but resistance due to regulatory T cell (Treg) infiltration…
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AACR 2024: TIL analysis demonstrates different mechanisms underlying PD-1 resistance in animal models
Used in the poster: B-hPD-1/hPD-L1 mice Summary: Resistance to PD-1 immunotherapy presents a significant challenge in cancer treatment, often associated with alterations in the tumor…
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AACR 2024: A first-in-class bispecific ADC targeting FOLR1 and MUC1 exhibits promising anti-tumor activity in a FOLR1low xenograft model
Used in the poster: BsAb Discovery Platform Summary: Folate receptor alpha (FOLR1) and MUC1 are overexpressed in various cancers, suggesting potential as therapeutic targets. A…
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AACR 2024: Generation of humanized PD-1/PD-L1/CD94/NKG2A mice for evaluating novel combination therapies
Used in the poster: B-hPD-1/hPD-L1/hCD94/hNKG2A mice Summary: We created a quadruple humanized mouse model expressing NKG2A, CD94, PD-1, and PD-L1 to investigate potential combination therapies.…
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AACR 2024: Development of humanized VEGFA models to assess preclinical efficacy of novel therapeutics in vivo
Used in the poster: B-hVEGFA mice Summary: Our study presents a novel humanized VEGFA model (B-hVEGFA mice) to investigate VEGFA-targeting therapies' efficacy in limiting cancer…
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AACR 2024: Establishment of humanized CD3EDG/4-1BB mice for testing novel T cell engagers
Used in the poster: B-hCD3EDG/h4-1BB mice Summary: We developed a novel humanized B-hCD3EDG/h4-1BB mouse model by crossing mice expressing chimeric CD3E, CD3D, and CD3G with…
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AACR 2024: Generation and validation of a novel humanized IL-31/IL-31RA/OSM/OSMR mouse model
Used in the poster: B-hIL31/hIL31RA/hOSM/hOSMR mice Summary: A novel preclinical mouse model was developed, expressing humanized IL-31, IL-31RA, OSM, and OSMR. This quadruple humanized model…
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AACR 2024: Validation of humanized TL1A mice for advancing preclinical research
Used in the poster: B-hTL1A mice Summary: We generated a human TL1A knock-in (B-hTL1A mice) mouse model. Human TL1A gene expression in B-hTL1A mice was…
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AET2023: Fully Human Anti-TIGIT Blocking Monoclonal Antibodies Demonstrate Potent Anti-Tumor Efficacy
Summary We obtained novel, differentiating, fully human anti-TIGIT clones with the following properties and activities • High binding affinity • Distinct epitopes from several clinical…
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AET2023: Discovery of a fully human TCR-mimic antibody developed to target NY-ESO-1/HLA-A02
Summary Biocytogen’s TCRm antibody discovery platform combines unique immune technology with a multiplex screening method to obtain a high-affinity NY-ESO-1/HLA-A02 antibody, which can bind and…
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AET2023: Discovery of RenNano®-derived human heavy-chain-only TFR1 antibodies that can efficiently cross the blood-brain barrier and deliver drug payload
Summary • hTFR1-targeting HCAbs developed from RenNano® mice have nM range affinity to human TFR1, and have functional capabilities, including internalization capacity. • hTFR1-targeting HCAbs…
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