AACR 2023: Discovery of BCG033, A Novel Anti-PTK7 x TROP2 Bispecific Antibody-Drug Conjugate with Promising Efficacy Against Triple-Negative Breast Cancer
Conclusions BCG033 is a novel and fully human bispecific PTK7 and TROP2 antibody-drug conjugate generated from the RenLite® platform. Cytotoxicity assays and internalization assays indicate…
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AACR 2023: BCG022: A Novel Bispecific Antibody-Drug Conjugate Targeting HER3 and MET
Conclusions BCG022 is a novel and fully human bispecific antibody-drug conjugate generated from the RenLite® platform that exhibits cross-species reactivity to human and cynomolgus monkey…
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AACR 2023: A First-In-Class Anti-HER2/TROP2 Bispecific Antibody-Drug Conjugate (YH012) Exhibits Potent Anti-Tumor Efficacy
Conclusions HER2 and TROP2 are co-expressed in a wide range of tumor types. Of note, TROP2 was also expressed in many HER2-low solid tumors, such…
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AACR 2023: Discovery of RenNano®-Derived Human Heavy-Chain-Only Antibodies That Cross the Blood-Brain-Barrier
Used in the poster: RenNano® platform Conclusions TFR1-targeting HCAbs developed from RenNano® mice have high affinity to human TFR1, and have functional capabilities, including internalization capacity.…
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AACR 2023: RenNano® Mice: A Heavy-Chain-Only Antibody Platform for the Generation of Nanobody Therapeutics
Used in the poster: RenNano® platform Conclusions RenNano® mice contain all human V,D, and J genes in situ with a modified murine constant region designed…
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AACR 2023: In vivo Efficacy of an Anti-Human IL11RA Antibody in B-hIL11RA Mice With APAP-Induced Liver Damage
Used in this poster: B-hIL11RA mice Conclusions mRNA expression analysis: Murine Il11ra1 mRNA was detected in liver tissue isolated from wild-type C57BL/6 (+/+) mice, while…
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AACR 2023: Targeting Intracellular Tumor Antigens Using Fully Human TCR Mimic Antibodies Derived From HLA Transgenic RenMice
Conclusions Biocytogen’s TCR-mimic (TCRm) antibody platform can be deployed to generate antibodies in vivo to target pHLA complexes for mutated proteins, viral oncoproteins, and cancer-testis…
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AACR 2023: B-hCD94/hNKG2A Mice Provide a Preclinical Tool for Evaluating Therapeutic Antibodies Targeting Human NKG2A
Used in this poster: B-hCD94/hNKG2A mice Conclusions mRNA expression analysis: Mouse Cd94 and Nkg2a mRNAs were detected in splenocytes isolated from wild-type mice, while human…
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AACR 2023: A Novel Triple Humanized B-hPD-1/hPD-L1/hCCR8 Mouse Model to Evaluate In vivo Efficacy of Combination Therapies
Used in the poster: B-hPD-1/hPD-L1/hCCR8 mice Conclusions Protein expression analysis: Human PD-1, PD-L1 and CCR8 proteins were detected in homozygous B-hPD-1/hPD-L1/hCCR8 mice, but not in…
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AACR 2023: *Novel Preclinical Candidates Targeting B7-H3, 6B5 and 10F7, Are Suitable for Development Into Various Drug Modalities
Conclusions 6B5 and 10F7, two anti-human B7-H3 clones, are preclinical candidates suitable for different modalities of B7-H3-targeted therapies. 6B5 is a high affinity, highly B7-H3-selective,…
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AACR 2023: D02, A Novel, Non-Blocking Antibody Targeting IL2RA, Exhibits Significant Anti-Tumor Activity in IL2RA-Humanized Mice
Conclusions D02 is a fully human IgG1 antibody specific to IL2RA that was obtained from RenMabTM humanized immunoglobulin mice. D02 binds both human and cynomolgus…
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PEGS-EU 2022: A Novel TCR-mimic Fully Human Antibody Discovery Platform
Conclusions With the development of immunotherapy in recent years, therapeutic antibodies have become a major player combating cancer with the limitation of recognizing cell surface…
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