SITC 2024: A novel IL12Rβ1 and IL12Rβ2 humanized mouse model for preclinical efficacy and toxicity evaluation of human IL-12 analogs

SITC 2024: A novel IL12Rβ1 and IL12Rβ2 humanized mouse model for preclinical efficacy and toxicity evaluation of human IL-12 analogs

Summary:

Functional Analysis:

• Human IL-12 induced IFN-γ production in CD4+ T cells sorted from splenocytes of homozygous B-hIL12RB1/hIL12RB2 mice.

In Vivo Toxicity Study:

• Human IL-12 increased %liver weight/BW and %spleen weight/BW.
• Human IL-12 induced IFN-γ production and showed a tendency to increase AST activity.