B-hIL17A Mice

January 21, 2020

IL17A encodes the pro-inflammatory cytokine IL17A that is a member of the interleukin-17 family. IL17A is produced by activated T helper (Th17) cells and certain cell types of innate immune system (Cua and Tato, Nat Rev Immunol.  2010, 10(7):479-89). IL17A functions as either a homodimer or a heterodimer with other IL17 family members, e.g. IL17F […]

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B-hIL4/IL4RA mice

January 21, 2020

IL4 (interleukin 4) encoded by this gene is a pleiotropic cytokine produced by activated T cells. IL4 is capable of binding to its receptor IL4R, while IL13 is also capable of binding to IL4R, which may result in a functional overlap of IL4 and IL13. IL-4 has immunomodulatory effects on B cells, T cells, mast […]

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B-hIL4 Mice

January 20, 2020

IL4 (interleukin 4) encoded by this gene is a pleiotropic cytokine produced by activated T cells. IL4 is capable of binding to its receptor IL4R, while IL13 is also capable of binding to IL4R, which may result in a functional overlap of IL4 and IL13. IL-4 has immunomodulatory effects on B cells, T cells, mast […]

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B-hIL4RA Mice

December 20, 2019

IL4R (interleukin 4 receptor) This gene encodes the alpha chain of the IL4 receptor and belongs to the type I transmembrane protein, which plays a huge role in the immune response. IL4R can bind to IL4 and IL13 to regulate the production of IgE, and binding to IL4 can promote the differentiation of Th2 cells, […]

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B-hPD-1/hPD-L1/hTIM3

December 5, 2019

PD-1 (Programmed death-1) is mainly expressed on the surface of T cells and primary B cells. The two PD-1 ligands, PD-L1 and PD-L2, are widely expressed on antigen-presenting cells (APCs). PD-1 interacts with its ligands and plays an important role in the negative regulation of the immune response. PD-L1 protein expression is detected in many […]

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B-hPD-1/hPD-L1/hCTLA4

December 5, 2019

PD-1 (Programmed death-1) is mainly expressed on the surface of T cells and primary B cells. The two PD-1 ligands, PD-L1 and PD-L2, are widely expressed on antigen-presenting cells (APCs). PD-L1 expression is favorable for tumorigenesis and growth, for induction of anti-tumor T cell apoptosis, and for escaping responses by the immune system. Inhibition of […]

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B-hTNFR2

December 5, 2019

TNFR2 is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1A. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate […]

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B-hIL17A Mice

July 2, 2019

IL17A encodes the pro-inflammatory cytokine IL-17A that is a member of the interleukin-17 family. IL-17A is produced by activated T helper (Th17) cells and certain cell types of innate immune system (Cua and Tato, Nat Rev Immunol. 2010, 10(7):479-89). IL-17A functions as either a homodimer or a heterodimer with other IL-17 family members, e.g. IL-17F […]

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B-hPD-1 Mice

June 7, 2019

PD-1 (Programmed death-1) is mainly expressed on the surface of T cells and primary B cells. The two PD-1 ligands, PD-L1 and PD-L2, are widely expressed on antigen-presenting cells (APCs).  PD-1 interacts with its ligands and plays an important role in the negative regulation of the immune response. PD-L1 protein expression is detected in many […]

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