B-hCD20 mice

September 16, 2021

CD20 is a 33-37 kD protein, a member of the MS4A family, with four transmembrane spanning regions that present as a homo-oligomeric complexes in the cell surface when associating with MHC class I and II, CD53, CD81, and CD82. CD20 is expressed on B cells and a subset of T cells, but not on plasma […]

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B-hCD16A mice(CB-17 SCID)

September 16, 2021

CD16 is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophils, monocytes, and macrophages, and has been identified as Fc receptors FcγRIIIa (CD16a, Low affinity immunoglobulin gamma Fc region receptor III-A. FCGR3A, gene ID 2214) and FcγRIIIb (CD16b), which participate in signal transduction. The most well-researched membrane receptor implicated in […]

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B-hCD89 mice

September 16, 2021

CD89, also known as FcαR, is a 55-100 kDa glycosylated protein. It belongs to the immunoglobulin gene family. It is expressed on granulocytes, monocytes, and macrophages but is absent on T cells. It can interact with IgA aggregates and plays an important role in IgA mediated immune responses. This gene is a member of the […]

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B-Tg(hLILRB2-hLILRB3) mice

September 16, 2021

Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All members of LIR subfamily B, contain a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and have an inhibitory function. Upon engagement of members of LIR subfamily B […]

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B-hCD40/hCD40L mice

September 16, 2021

CD40 (CD40 molecule) is a member of the tumor necrosis factor receptor superfamily expressed on antigen-presenting cells (APC), such as dendritic cells (DC), B cells, and monocytes as well as many non-immune cells and a wide range of tumors [1]. Engagement with its trimeric ligand CD154 on activated T helper cells results in APC activation, […]

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B-hIL17RA mice

September 16, 2021

Interleukin 17 receptor A (IL17RA) is also known as cluster of differentiation w217 (CDw217), is a pro-inflammatory cytokine secreted by activated T-lymphocytes, belong to ubiquitous type I membrane glycoprotein, and binds with low affinity to interleukin 17A (IL17A). IL 17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and […]

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B-hIL17RB mice

September 16, 2021

IL17RB (interleukin 17 receptor B, gene ID 55540), also known asCRL4 or EVI27 or IL17BR or IL17RH1, encodes a single-pass type I membrane protein. The protein is a cytokine receptor of the interleukin 17 (IL-17) family of cytokines. Human and mouse IIL-17 RB share 76% amino acid (aa) sequence identity. By Northern blot analysis, human […]

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B-hIL9R mice

September 16, 2021

Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a type I cytokine receptor. The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), […]

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