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B-hIL17A Mice

July 2, 2019

IL17A encodes the pro-inflammatory cytokine IL-17A that is a member of the interleukin-17 family. IL-17A is produced by activated T helper (Th17) cells and certain cell types of innate immune system (Cua and Tato, Nat Rev Immunol. 2010, 10(7):479-89). IL-17A functions as either a homodimer or a heterodimer with other IL-17 family members, e.g. IL-17F […]

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B-hPD-1 Mice

June 7, 2019

PD-1 (Programmed death-1) is mainly expressed on the surface of T cells and primary B cells. The two PD-1 ligands, PD-L1 and PD-L2, are widely expressed on antigen-presenting cells (APCs).  PD-1 interacts with its ligands and plays an important role in the negative regulation of the immune response. PD-L1 protein expression is detected in many […]

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B-hTNFRSF18 (GITR) Mice

June 5, 2019

TNFRSF18 (TNF Receptor Superfamily Member 18) is also known as Glucocorticoid-induced TNFR-related protein (GITR), which is expressed on many immune cells including T cells. As a co-stimulatory signal of T cells, TNFRSF18 is upregulated upon the activation of T cells, and in turn promotes T cell proliferation. CD25+/CD4+ regulatory T cell is known to mediate […]

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