B-NDG B2m KO mice plus
July 24, 2020
Human PBMC-engrafted humanized mice are attractive models for in vivo analysis of human immune responses. We previously reported that human PBMCs could be engrafted in B-NDG mice successfully.However, because of severe xenogeneic graft versus host disease (xeno-GVHD) in these mice, there is a limited window for experimentation. This makes it difficult to analyze human immune […]
B-hLAG3 mice plus
June 22, 2020
LAG3 (Lymphocyte activation gene 3, CD223) is a lymphocyte activation gene and a member of the Ig family. It is mainly expressed in activated T cells, NK cells, B cells and plasmacytoid DCs. LAG3 is a negative regulator of immunity and mainly binds to MHC class Ⅱ molecules to regulate the function of dendritic cells. […]
B-hCD38 mice
June 22, 2020
CD38 is a 42 kD glycoprotein, also known as T10. It is an ADP-ribosyl hydrolase, expressed on B cells, NK cells, a subset of T cells, brain, muscle, and kidney. In mouse, CD38 expression is downregulated on germinal center B cells and plasma cells, whereas this is not the case for humans. By functioning as […]
B-hB7-H3 mice
June 22, 2020
CD276 (Cluster of Differentiation 276) is a human protein encoded by the CD276 gene and belongs to the immunoglobulin superfamily. The transcript of B7-H3 is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. B7H3 is expressed on immune cells (such as antigen-presenting cells or macrophages) and […]
B-HLA-A2.1 mice
June 22, 2020
Transgenic mice that express human HLA molecules represent a unique in vivo experimental model for evaluating human immune system function.These models have been used to study the role of the human class I or class Il restricted T cell repertoire in autoimmune disease, infectious disease, and vaccine development. They are also valued tools for evaluating […]
B-hSIGLEC15 mice
June 22, 2020
SIGLEC15 (Sialic acid-binding immunoglobulin-like lectin 15) belongs to Siglec (sialic acid binding ig-like lectin), also known as CD33 antigen-like 3, and binds sialic acid type I transmembrane protein. SIGLEC15 is DAP12 (DNAX activating protein 12 kDa) related immune receptors, DAP12 is based on the immune activated receptor tyrosine motif (ITAM, immuno-receptor tyrosine -based activation motif) […]
B-hCCR4 mice
June 22, 2020
C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. CCR4 has also recently been designated CD194 (cluster of differentiation 194). CCR4 belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines: CCL2, CCL4, CCL5, CCL17, CCL22. Chemokines are a group of […]
B-hCD73 mice
June 22, 2020
CD73 is expressed on the surface of multiple cells of the immune system including T-cells, B-cells, NK-cells and myeloid-derived suppressor cells. CD73 catalyzes the final hydrolysis of AMP to adenosine following CD39 activity. Increased expression of CD73 has been associated with several tumor signaling pathways stimulated by hypoxyia in the TME. Anti-CD73 therapy in combination […]
B-hIL6/hIL6R mice
May 31, 2020
IL6 encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into […]
B-hCD39 mice
May 31, 2020
CD39, nucleoside triphosphate diphosphohydrolase-1 (NTPDase 1), is an ectoenzyme that degrades ATP to AMP. It is a member of ectonucleoside triphosphate dihydrolases (E-NTPDases) which are involved in regulation of extracellular nucleotide catabolism and controlling the extracellular nucleoside triphosphate pool (NTP). CD39 is the dominant member of this family in the immune system and involved in […]
