B-hPD-L1/hB7-H3 MC38
June 6, 2022
The human PD-L1 and chimeric CDS including human B7-H3 were inserted into counterpart gene sites separately, so that the mouse Pd-l1 and B7-h3 were not expressed anymore, human PD-L1 and B7-H3 protein were highly expressed on the surface of B-hPD-L1/hB7-H3 MC38 cells.
B-hGPC3 MC38 plus
June 6, 2022
B-hGUCY2C MC38
June 6, 2022
The chimeric CDS consist of human GUCY2C extracellular plus mouse Gucy2c intracellular region sequences was inserted to mouse Gucy2c gene exon 1 in B-hGUCY2C MC38 cells, so that the mouse GUCY2C was not expressed anymore, human GUCY2C was highly expressed on the surface of B-hGUCY2C MC38 cells.
B-hMSLN ID8
June 6, 2022
The human MSLN coding sequences were inserted to mouse Msln gene exon 2 in B-hMSLN ID8 cells, so that the mouse MSLN was not expressed anymore, human MSLN was highly expressed on the surface of B-hMSLN ID8 cells.
B-Tg(mAreg) MC38
June 6, 2022
B-Tg(mGpa33) MC38
June 6, 2022
B-hCTLA4/hCCR8 mice
June 6, 2022
B-hIL2RB/hIL2RG/hIL15/hIL15RA mice
June 6, 2022
B-hTDGF1 mice
June 6, 2022
B-hCXCR3 mice
June 3, 2022
