B-PD-1-EGFP mice

November 5, 2020

PD-1 (Programmed death-1) is mainly expressed on the surface of T cells and primary B cells. The two PD-1 ligands, PD-L1 and PD-L2, are widely expressed on antigen-presenting cells (APCs). PD-1 interacts with its ligands and plays an important role in the negative regulation of the immune response. PD-L1 protein expression is detected in many […]

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B-hILl7A/hIL17F mice

November 5, 2020

IL17A encodes the pro-inflammatory cytokine IL17A that is a member of the interleukin-17 family. IL17A is produced by activated T helper (Th17) cells and certain cell types of innate immune system (Cua and Tato, Nat Rev Immunol. 2010, 10(7):479-89). IL17A functions as either a homodimer or a heterodimer with other IL17 family members, e.g. IL17F […]

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B-hPD-1/hPD-L1/hCD40 mice

November 5, 2020

PD-1 (Programmed death-1) is mainly expressed on the surface of T cells and primary B cells. The two PD-1 ligands, PD-L1 and PD-L2, are widely expressed on antigen-presenting cells (APCs). PD-1 interacts with its ligands and plays an important role in the negative regulation of the immune response. PD-L1 protein expression is detected in many […]

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B-hCD226 mice

November 5, 2020

This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in […]

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B-hCD73 mice plus

October 31, 2020

CD73 is expressed on the surface of multiple cells of the immune system including T-cells, B-cells, NK-cells and myeloid-derived suppressor cells. CD73 catalyzes the final hydrolysis of AMP to adenosine following CD39 activity. Increased expression of CD73 has been associated with several tumor signaling pathways stimulated by hypoxyia in the TME. Anti-CD73 therapy in combination […]

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B-hIL12A/hIL12B mice

October 23, 2020

Gene description Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells,macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 belongs to the family of interleukin-12. IL-12 family is unique in comprising the only heterodimeric cytokines, which includes IL-12, IL-23, IL-27 and IL-35. Despite sharing many structural features and molecular partners, they mediate surprisingly diverse functional effects. IL-12 […]

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B-hETAR mice

October 21, 2020

ETAR gene (ortholog gene in mouse was Ednra) encodes endothelin-A receptor, a member of the endothelin receptor group of G-protein-coupled receptors. consist of an extracellular glycosylated N-terminal domain followed by transmembrane regions containing seven hydrophobic α-helices. The transmembrane domains are linked via three shorter extracellular and intracellular loops. ETAR located primarily in the vascular endothelial […]

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B-hPD-1/hPD-L1/hCTLA4 mice

October 20, 2020

PD-1 (Programmed death-1) is mainly expressed on the surface of T cells and primary B cells. The two PD-1 ligands, PD-L1 and PD-L2, are widely expressed on antigen-presenting cells (APCs). PD-L1 expression is favorable for tumorigenesis and growth, for induction of anti-tumor T cell apoptosis, and for escaping responses by the immune system. Inhibition of […]

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B-hIL13 mice

October 14, 2020

Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located on chromosome 5q31 with a length of 1.4kb. It has a mass of 13 kDa and folds into 4 alpha helical bundles. The secondary structural features of IL-13 are similar to […]

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