B-hSORT1 mice plus

March 11, 2024

SORT1 (Sortilin) is a vital regulator that reduces PGRN levels in plasma and the brain by transporting it into cells for degradation. It’s also a transmembrane protein overexpressed in many cancers, playing a key role in protein internalization, sorting, and transportation. The coding sequences of human SORT1 were inserted to replace part of murine exon […]

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