B-hGLP1R mice
May 22, 2021
The glucagon-like peptide-1 receptor (GLP1R) is a receptor protein found on beta cells of the pancreas and on neurons of the brain. It is involved in the control of blood sugar level by enhancing insulin secretion. In humans it is synthesized by the gene GLP1R, which is present on chromosome 6. It is a member […]
B-hPD-1/hPD-L1/hGITR mice
May 22, 2021
PD-1 (Programmed death-1) is mainly expressed on the surface of T cells and primary B cells. The two PD-1 ligands, PD-L1 and PD-L2, are widely expressed on antigen-presenting cells (APCs). PD-1 interaction with its ligands negatively regulates the immune response. PD-L1 protein expression is detected in many human tumor tissues. PD-L1 expression in tumor cells […]
B-hPD-1/hB7-H3 mice
May 22, 2021
PD-1 (Programmed death-1) is mainly expressed on the surface of T cells and primary B cells. The two PD-1 ligands, PD-L1 and PD-L2, are widely expressed on antigen-presenting cells (APCs). PD-L1 expression is favorable for tumorigenesis and growth, for induction of anti-tumor T cell apoptosis, and for escaping responses by the immune system. Inhibition of […]
B-hGCGR mice
May 22, 2021
GCGR encodes a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM). Activation of the human glucagon receptor (GCGR) by its endogenous ligand glucagon triggers the release of glucose from the liver during fasting, making it a potential drug target for type […]
B-hHLA-E MC38 plus
May 17, 2021
The mouse H2-T23 gene was replaced by human HLA-E coding sequence in B-hHLA-E MC38 plus cells. Human HLA-E is highly expressed on the surface of B-hHLA-E MC38 plus cells.
B-hPD-L1 plus/hCEA MC38
May 13, 2021
The mouse Pdl1 gene and Ceacam5 gene were replaced by human PD-L1 and CEACAM5 coding sequence in B-hPD-L1 plus/hCEA MC38 cells. Human PD-L1 and CEACAM5 are highly expressed on the surface of B-hPD-L1 plus/hCEA MC38 cells.
B-hPD-L1 plus/hCD47 MC38
May 13, 2021
The mouse Pdl1 gene and Cd47 gene were replaced by human PD-L1 and CD47 coding sequence in B-hPD-L1 plus/hCD47 MC38 cells. Human PD-L1 and CD47 are highly expressed on the surface of B-hPD-L1 plus/hCD47 MC38 cells.
B-mSiglec15 MC38
May 13, 2021
The mouse Siglec15 gene was insert into mouse ROSA26 site. Mouse Siglec15 is highly expressed on the surface of B-mSiglec15 MC38 cells.
B-hTPBG MC38
May 13, 2021
The mouse Tpbg gene was replaced by human TPBG coding sequence in B-hTPBG MC38 cells. Human TPBG is highly expressed on the surface of B-hTPBG MC38 cells.
B-hSIGLEC15 MC38
May 13, 2021
The mouse Siglec15 gene was replaced by human SIGLEC15 coding sequence in B-hSIGLEC15 MC38 cells. Human SIGLEC15 is highly expressed on the surface of B-hSIGLEC15 MC38 cells.
